AgNPs Targeting the Drug Resistance Problem of Staphylococcus aureus: Susceptibility to Antibiotics and Efflux Effect
| Parent link: | Pharmaceutics Vol. 14, iss. 4.— 2022.— [763, 15 p.] |
|---|---|
| Autor corporatiu: | |
| Altres autors: | , , , , , |
| Sumari: | Title screen The present work presents translational research with application of AgNPs targeting the global drug resistance problem. In vivo fieldwork was carried out with 400 breeding farm cows sick with a serous mastitis. Ex vivo results revealed that after cow treatment with LactobayTM (a mixture of antibiotic drugs) the susceptibility to 31 antibiotics of S. aureus isolates from cow breast secretion decreased by 25%, while after treatment with Argovit-CTM silver nanoparticles S. aureus susceptibility increased by 11%. The portion of isolates with an efflux effect leading to elimination of antibiotics from S. aureus after Lactobay-treatment resulted in a 15% increase, while Argovit-C-treatment led to a 17.5% decrease. The obtained results showed that mastitis treatments with Argovit-CTM AgNPs can partially restore the activity of antibiotics towards S. aureus and shorten the duration of mastitis treatment by 33%. |
| Idioma: | anglès |
| Publicat: |
2022
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| Matèries: | |
| Accés en línia: | https://doi.org/10.3390/pharmaceutics14040763 |
| Format: | Electrònic Capítol de llibre |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=667765 |
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| 200 | 1 | |a AgNPs Targeting the Drug Resistance Problem of Staphylococcus aureus: Susceptibility to Antibiotics and Efflux Effect |f E. Nefedova, N. Shkil, R. L. Vazquez-Gomez [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 45 tit.] | ||
| 330 | |a The present work presents translational research with application of AgNPs targeting the global drug resistance problem. In vivo fieldwork was carried out with 400 breeding farm cows sick with a serous mastitis. Ex vivo results revealed that after cow treatment with LactobayTM (a mixture of antibiotic drugs) the susceptibility to 31 antibiotics of S. aureus isolates from cow breast secretion decreased by 25%, while after treatment with Argovit-CTM silver nanoparticles S. aureus susceptibility increased by 11%. The portion of isolates with an efflux effect leading to elimination of antibiotics from S. aureus after Lactobay-treatment resulted in a 15% increase, while Argovit-C-treatment led to a 17.5% decrease. The obtained results showed that mastitis treatments with Argovit-CTM AgNPs can partially restore the activity of antibiotics towards S. aureus and shorten the duration of mastitis treatment by 33%. | ||
| 461 | |t Pharmaceutics | ||
| 463 | |t Vol. 14, iss. 4 |v [763, 15 p.] |d 2022 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a AgNPs | |
| 610 | 1 | |a lactobay | |
| 610 | 1 | |a S. aureus | |
| 610 | 1 | |a efflux effect | |
| 610 | 1 | |a стафилококки | |
| 610 | 1 | |a антибиотики | |
| 610 | 1 | |a лечение | |
| 701 | 1 | |a Nefedova |b E. |g Ekaterina | |
| 701 | 1 | |a Shkil |b N. |g Nikolay | |
| 701 | 1 | |a Vazquez-Gomez |b R. L. |g Roberto Luna | |
| 701 | 1 | |a Garibo |b D. |g Diana | |
| 701 | 1 | |a Pestryakov |b A. N. |c Chemist |c Professor of Tomsk Polytechnic University, Doctor of Chemical Science |f 1963- |g Aleksey Nikolaevich |3 (RuTPU)RU\TPU\pers\30471 |9 14796 | |
| 701 | 1 | |a Bogdanchikova |b N. |g Nina | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Исследовательская школа химических и биомедицинских технологий |c (2017- ) |3 (RuTPU)RU\TPU\col\23537 |
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| 856 | 4 | |u https://doi.org/10.3390/pharmaceutics14040763 | |
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