Development of Mixed metal Metal-organic polyhedra networks, colloids, and MOFs and their Pharmacokinetic applications; Scientific Reports; Vol. 7
| Parent link: | Scientific Reports Vol. 7.— 2017.— [832, 8 p.] |
|---|---|
| Körperschaft: | |
| Weitere Verfasser: | , , , , , , |
| Zusammenfassung: | Title screen The coordination networking of discrete metal-organic polyhedra (MOPs) involving different ligands as well as metals is a challenging task due to the features of limited solubility and chemical stability of these polyhedra. An unusual approach, ligand-oriented polyhedral networking via click chemistry and further metal coordination is reported here. An alkyne decorated Cu(II)-MOP self-catalyzes the regioselective click reaction (1,3-dipolar cycloaddition) using azide-functionalized ligands under unconventional reaction conditions. Introducing new metal ions, M(II), interlinks the carboxylic groups on the MOP surfaces creating coordination networks. On the other hand, exposure of the respective individual ligand components in the presence of Cu(II) promotes an in-situ click reaction along with metal coordination generating a new 3D-framework. These materials demonstrated a high drug hosting potential exhibiting a controlled progressive release of anticancer (5-flourouracil) and stimulant (caffeine) drugs in physiological saline at 37°C. These innovative and unconventional MOP networks provide a significant conceptual advance in understanding. |
| Sprache: | Englisch |
| Veröffentlicht: |
2017
|
| Schlagworte: | |
| Online-Zugang: | https://doi.org/10.1038/s41598-017-00733-4 |
| Format: | MixedMaterials Elektronisch Buchkapitel |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=667251 |
MARC
| LEADER | 00000naa0a2200000 4500 | ||
|---|---|---|---|
| 001 | 667251 | ||
| 005 | 20250307142231.0 | ||
| 035 | |a (RuTPU)RU\TPU\network\38456 | ||
| 035 | |a RU\TPU\network\38103 | ||
| 090 | |a 667251 | ||
| 100 | |a 20220310d2017 k||y0rusy50 ba | ||
| 101 | 0 | |a eng | |
| 135 | |a drcn ---uucaa | ||
| 181 | 0 | |a i | |
| 182 | 0 | |a b | |
| 200 | 1 | |a Development of Mixed metal Metal-organic polyhedra networks, colloids, and MOFs and their Pharmacokinetic applications |f N. Ahmad, H. A. Younus, A. H. Chughtai [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 24 tit.] | ||
| 330 | |a The coordination networking of discrete metal-organic polyhedra (MOPs) involving different ligands as well as metals is a challenging task due to the features of limited solubility and chemical stability of these polyhedra. An unusual approach, ligand-oriented polyhedral networking via click chemistry and further metal coordination is reported here. An alkyne decorated Cu(II)-MOP self-catalyzes the regioselective click reaction (1,3-dipolar cycloaddition) using azide-functionalized ligands under unconventional reaction conditions. Introducing new metal ions, M(II), interlinks the carboxylic groups on the MOP surfaces creating coordination networks. On the other hand, exposure of the respective individual ligand components in the presence of Cu(II) promotes an in-situ click reaction along with metal coordination generating a new 3D-framework. These materials demonstrated a high drug hosting potential exhibiting a controlled progressive release of anticancer (5-flourouracil) and stimulant (caffeine) drugs in physiological saline at 37°C. These innovative and unconventional MOP networks provide a significant conceptual advance in understanding. | ||
| 461 | |t Scientific Reports | ||
| 463 | |t Vol. 7 |v [832, 8 p.] |d 2017 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a металлы | |
| 610 | 1 | |a полиэдры | |
| 610 | 1 | |a растворимость | |
| 610 | 1 | |a стабильность | |
| 610 | 1 | |a лекарственные средства | |
| 610 | 1 | |a противоопухолевые препараты | |
| 701 | 1 | |a Ahmad |b N. |g Nazir | |
| 701 | 1 | |a Younus |b H. A. |g Hussein | |
| 701 | 1 | |a Chughtai |b A. H. |g Adeel | |
| 701 | 1 | |a Hecke |b K. V. |g Kristof Van | |
| 701 | 1 | |a Danish |b M. |g Muhammad | |
| 701 | 1 | |a Gaoke |b Zh. |g Zhang | |
| 701 | 1 | |a Verpoort |b F. V. K. |c Chemical Engineer |c Professor of Tomsk Polytechnic University, doctor of chemical Sciences |f 1963- |g Frensis Valter Kornelius |3 (RuTPU)RU\TPU\pers\35059 |9 18334 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет (ТПУ) |b Энергетический институт (ЭНИН) |b Кафедра автоматизации теплоэнергетических процессов (АТП) |3 (RuTPU)RU\TPU\col\18678 |
| 801 | 2 | |a RU |b 63413507 |c 20220310 |g RCR | |
| 856 | 4 | |u https://doi.org/10.1038/s41598-017-00733-4 | |
| 942 | |c CF | ||