Association of Polymorphisms of Serotonin Transporter (5HTTLPR) and 5-HT2C Receptor Genes with Criminal Behavior in Russian Criminal Offenders; Neuropsychobiology; Vol. 75, iss. 4

Association of Polymorphisms of Serotonin Transporter (5HTTLPR) and 5-HT2C Receptor Genes with Criminal Behavior in Russian Criminal Offenders; Neuropsychobiology; Vol. 75, iss. 4

Bibliographische Detailangaben
Parent link:Neuropsychobiology
Vol. 75, iss. 4.— 2017.— [P. 200-210]
Körperschaft: Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Лаборатория радиационного контроля № 31 (Лаборатория РК № 31)
Weitere Verfasser: Toshchakova V. A., Bakhtiari Y., Kulikov A. V., Gusev S. I., Trofimova M. V., Fedorenko O. Yu. Olga Yurievna, Mikhalitskaya E. V., Popova N. K., Bokhan N. A., Hovens J. E., Loonen A. J. M., Wilffert B., Ivanova S. A. Svetlana Aleksandrovna
Zusammenfassung:Title screen
Background: Human aggression is a heterogeneous behavior with biological, psychological, and social backgrounds. As the biological mechanisms that regulate aggression are components of both reward-seeking and adversity-fleeing behavior, these phenomena are difficult to disentangle into separate neurochemical processes. Nevertheless, evidence exists linking some forms of aggression to aberrant serotonergic neurotransmission. We determined possible associations between 6 serotonergic neurotransmission-related gene variants and severe criminal offenses. Methods: Male Russian prisoners who were convicted for murder (n = 117) or theft (n = 77) were genotyped for variants of the serotonin transporter (5HTTLPR), tryptophan hydroxylase, tryptophan-2,3-dioxygenase, or type 2C (5-HT2C) receptor genes and compared with general-population male controls (n = 161). Prisoners were psychologically phenotyped using the Buss-Durkee Hostility Inventory and the Beck Depression Inventory. Results: No differences were found between murderers and thieves either concerning genotypes or concerning psychological measures. Comparison of polymorphism distribution between groups of prisoners and controls revealed highly significant associations of 5HTTLPR and 5-HTR2C (rs6318) gene polymorphisms with being convicted for criminal behavior. Conclusions: The lack of biological differences between the 2 groups of prisoners indicates that the studied 5HT-related genes do not differentiate between the types of crimes committed.
Sprache:Englisch
Veröffentlicht: 2017
Schlagworte:
электронный ресурс
труды учёных ТПУ
aggression
serotonin transporter
5-HT2C receptor
genotype
генотипы
полиморфизм
серотонины
Online-Zugang:https://doi.org/10.1159/000487484
Format: MixedMaterials Elektronisch Buchkapitel
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=667062

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