Detection of trace amounts of insoluble pharmaceuticals in water by extraction and SERS measurements in a microfluidic flow regime; Analyst; Vol. 146, iss. 11

Detection of trace amounts of insoluble pharmaceuticals in water by extraction and SERS measurements in a microfluidic flow regime; Analyst; Vol. 146, iss. 11

Bibliographic Details
Parent link:Analyst
Vol. 146, iss. 11.— 2021.— [P. 3686-3696]
Corporate Author: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Other Authors: Burtsev V., Erzina M. R. Mariya Rashidovna, Kalacheva G. G. Galina Grigorjevna, Svorcik V. Vaclav, Lyutakov O. Oleksy, Milyutina (Miliutina) E. V. Elena Vadimovna, Guselnikova O. A. Olga Andreevna
Summary:Title screen
Detection of trace amounts of poorly water-soluble pharmaceuticals or related (bio)solutions represents a key challenge in environment protection and clinical diagnostics. However, this task is complicated by low concentrations of pharmaceuticals, complex sample matrices, and sophisticated sample preparative routes. In this work, we present an alternative approach on the basis of an on-line flow extraction procedure and SERS measurements performed in a microfluidic regime. The advantages of our approach were demonstrated using ibuprofen (Ibu), which is considered as a common pharmaceutical contaminant in wastewater and should be monitored in various bioliquids. The extraction of Ibu from water to the dichloromethane phase was performed with an optimized microfluidic mixer architecture. As SERS tags, lipophilic functionalized gold multibranched nanoparticles (AuMs) were added to the organic phase. After microfluidic extraction, Ibu was captured by the functionalized AuM surface and recognized by on-line SERS measurements with up to 10–8 M detection limit. The main advantages of the proposed approach can be regarded as its simplicity, lack of need for preliminary sample preparation, high reliability, the absence of sample pretreatment, and low detection limits.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2021
Subjects:
электронный ресурс
труды учёных ТПУ
фармацевтические препараты
экстракция
потоки
загрязнители
биожидкости
Online Access:https://doi.org/10.1039/D0AN02360D
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=666488

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