Association of PIP4K2A Polymorphisms with Alcohol Use Disorder; Genes; Vol. 12, iss. 10
| Parent link: | Genes Vol. 12, iss. 10.— 2021.— [1642, 7 p.] |
|---|---|
| Autor Corporativo: | |
| Outros Autores: | , , , , , |
| Resumo: | Title screen Background: Alcohol use disorder (AUD) not only influences individuals and families but also has a lasting social impact on communities at the national level. Dopaminergic neurotransmission is involved in excessive alcohol consumption. Phosphatidylinositol-5-phosphate-4-kinase type 2 [alpha] (PIP4K2A) plays an important role in the regulation of ascending dopamine pathways. In this study; we determined possible associations between nine polymorphisms in PIP4K2A and AUD in Russian men. Methods: 279 Russian men with AUD were investigated. The control group consisted of 222 healthy men from the general Russian population. Genotyping of DNA samples for nine polymorphic variants of PIP4K2A was carried out by the Applied Biosystems™ QuantStudio™ 5 Real-Time PCR System with use of the TaqMan1 Validated SNP Genotyping Assay (Applied Biosystems; CIIIA). Results: Carriage of the PIP4K2A rs2230469*TT/T genotype/allele was a relative risk factor for developing AUD in men (p=0.026 and p=0.0084 accordingly). Moreover; men with AUD had a higher frequency of PIP4K2A rs746203*T allele (p=0.023) compared to healthy men. Conclusions: For the first time; we demonstrated different PIP4K2A polymorphisms to be associated with AUD presumably due to dopamine system modulation resulting from regulation of the lateral habenula. |
| Idioma: | inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://doi.org/10.3390/genes12101642 |
| Formato: | MixedMaterials Recurso Electrónico Capítulo de Livro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=666446 |
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| 200 | 1 | |a Association of PIP4K2A Polymorphisms with Alcohol Use Disorder |f O. Yu. Fedorenko, E. V. Mikhalitskaya, V. A. Toshchakova [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 33 tit.] | ||
| 330 | |a Background: Alcohol use disorder (AUD) not only influences individuals and families but also has a lasting social impact on communities at the national level. Dopaminergic neurotransmission is involved in excessive alcohol consumption. Phosphatidylinositol-5-phosphate-4-kinase type 2 [alpha] (PIP4K2A) plays an important role in the regulation of ascending dopamine pathways. In this study; we determined possible associations between nine polymorphisms in PIP4K2A and AUD in Russian men. Methods: 279 Russian men with AUD were investigated. The control group consisted of 222 healthy men from the general Russian population. Genotyping of DNA samples for nine polymorphic variants of PIP4K2A was carried out by the Applied Biosystems™ QuantStudio™ 5 Real-Time PCR System with use of the TaqMan1 Validated SNP Genotyping Assay (Applied Biosystems; CIIIA). Results: Carriage of the PIP4K2A rs2230469*TT/T genotype/allele was a relative risk factor for developing AUD in men (p=0.026 and p=0.0084 accordingly). Moreover; men with AUD had a higher frequency of PIP4K2A rs746203*T allele (p=0.023) compared to healthy men. Conclusions: For the first time; we demonstrated different PIP4K2A polymorphisms to be associated with AUD presumably due to dopamine system modulation resulting from regulation of the lateral habenula. | ||
| 338 | |b Российский фонд фундаментальных исследований |d 19-315-90032 | ||
| 461 | |t Genes | ||
| 463 | |t Vol. 12, iss. 10 |v [1642, 7 p.] |d 2021 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a alcohol use disorder | |
| 610 | 1 | |a PIP4K2A | |
| 610 | 1 | |a polymorphisms | |
| 610 | 1 | |a расстройства | |
| 610 | 1 | |a алкогольная зависимость | |
| 610 | 1 | |a дофаминовая система | |
| 701 | 1 | |a Fedorenko |b O. Yu. |c specialist in the field of ecology and life safety |c Professor of Tomsk Polytechnic University, doctor of medical sciences |f 1973- |g Olga Yurievna |3 (RuTPU)RU\TPU\pers\33861 |9 17450 | |
| 701 | 1 | |a Mikhalitskaya |b E. V. | |
| 701 | 1 | |a Toshchakova |b V. A. |g Valentina Aleksandrovna | |
| 701 | 1 | |a Loonen |b A. J. M. |g Anton | |
| 701 | 1 | |a Bokhan |b N. A. |g Nikolay Aleksandrovich | |
| 701 | 1 | |a Ivanova |b S. A. |c specialist in the field of ecology and life safety |c Professor of Tomsk Polytechnic University, doctor of medical sciences |f 1964- |g Svetlana Aleksandrovna |3 (RuTPU)RU\TPU\pers\33859 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Инженерная школа неразрушающего контроля и безопасности |b Отделение контроля и диагностики |3 (RuTPU)RU\TPU\col\23584 |
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| 856 | 4 | |u https://doi.org/10.3390/genes12101642 | |
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