Preliminary Pharmacogenetic Study to Explore Putative Dopaminergic Mechanisms of Antidepressant Action; Journal of Personalized Medicine; Vol. 11, iss. 8

Preliminary Pharmacogenetic Study to Explore Putative Dopaminergic Mechanisms of Antidepressant Action; Journal of Personalized Medicine; Vol. 11, iss. 8

書誌詳細
Parent link:	Journal of Personalized Medicine Vol. 11, iss. 8.— 2021.— [731, 8 p.]
団体著者:	Национальный исследовательский Томский политехнический университет Инженерная школа неразрушающего контроля и безопасности Отделение контроля и диагностики
その他の著者:	Ochi T. Taichi, Vyalova N. M. Nataljya Mikhaylovna, Losenkov I. S. Innokenty Sergeevich, Paderina D. Z. Diana, Pozhidaev I. V. Ivan Vyacheslavovich, Loonen A. J. M. Anton, Simutkin G. G. German Gennadjevich, Bokhan N. A. Nikolay Aleksandrovich, Wilffert B. Bob, Ivanova S. A. Svetlana Aleksandrovna
要約:	Title screen Background: There is sufficient evidence that interference of dopaminergic neurotransmission contributes to the therapeutic effects of antidepressants in unipolar and bipolar depression. Methods: Hamilton depression rating scale (HAMD 17) scores of 163 at least moderately ill patients with major depressive disorders were used to establish treatment response. HAMD 17 score status was measured before initiation, after two weeks, and after four weeks of treatment with various antidepressants. The possible association between response and genotype in a total of 14 variants of dopamine neurotransmission-related proteins was investigated. Results: DRD4 rs11246226 CA heterozygous patients were found with a greater improvement of HAMD 17 score when compared to homozygous C patients during 0-2 weeks and 0-4 weeks. Patients with MAOB rs1799836 heterozygous GA and homozygous A also demonstrated improved scores during 2-4 weeks and 0-4 weeks. Conclusions: The results are preliminary due to the limited population size and the small number of variants. Further research into the involvement of habenular dopamine D4 receptors in the antidepressant response is desirable.
言語:	英語
出版事項:	2021
主題:	электронный ресурс труды учёных ТПУ dopaminergic pathway depression antidepressants mood disorders dopamine pharmacogenetics депрессия антидепрессанты расстройства
オンライン･アクセス:	https://doi.org/10.3390/jpm11080731
フォーマット:	電子媒体図書の章
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=666406

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