Solution blow spinning of PLLA/hydroxyapatite composite scaffolds for bone tissue engineering

Solution blow spinning of PLLA/hydroxyapatite composite scaffolds for bone tissue engineering

Bibliographic Details
Parent link:Biomedical Materials
Vol. 16, iss. 5.— 2021.— [055005, 18 p.]
Corporate Authors: Национальный исследовательский Томский политехнический университет Инженерная школа ядерных технологий Лаборатория плазменных гибридных систем, Национальный исследовательский Томский политехнический университет Инженерная школа ядерных технологий Научно-образовательный центр Б. П. Вейнберга
Other Authors: Popkov A. V. Aleksandr Viktorovich, Kulbakin D. E. Denis Evgenjevich, Popkov V. V. Vyacheslav Vladimirovich, Gorbach E. N. Elena Nikolaevna, Kononovich N. A. Nataljya Andreevna, Danilenko N. V. Nadezhda Viktorovna, Stankevich K. S. Ksenia Sergeevna, Choynzonov E. L. Evgeny Lkhamatsyrenovich, Zheravin A. A. Aleksandr Aleksandrovich, Khlusov I. A. Igor Albertovich, Bondar L. N. Ludmila Nikolaevna, Perelmuter V. M. Vladimir Mikhaylovich, Bolbasov E. N. Evgeny Nikolaevich, Tverdokhlebov S. I. Sergei Ivanovich
Summary:Title screen
Composite poly-L-lactide acid-based scaffolds with hydroxyapatite (HAp) content up to 75 wt.% were fabricated via solution blow spinning. The influence of HAp concentration on structure, wettability, mechanical properties and chemical and phase composition of the produced materials was examined. It was found that with an increase of HAp content the average fiber diameter was increased, the uniaxial strength and relative elongation were reduced, while the phase composition and surface wettability did not change. The performance of the scaffolds during implantation in the parietal bone of a rat skull for a period from 15 to 90 days was studied. The materials have shown high ability to integrate with both soft and hard tissues. It was found that scaffolds with 25 wt.% HAp content significantly enhance osteogenesis during scarification (damage) of the periosteum. Overall, the fabricated scaffolds proved to be highly efficient for replacing bone defects in long tubular bones.
Published: 2021
Subjects:
электронный ресурс
труды учёных ТПУ
Online Access:https://doi.org/10.1088/1748-605X/ac11ca
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=665613

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