Genetic polymorphisms of PIP5K2A and course of schizophrenia; BMC Medical Genetics; Vol. 21
| Parent link: | BMC Medical Genetics Vol. 21.— 2020.— [171, 9 p.] |
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| Corporate Authors: | , |
| Other Authors: | , , , , , , |
| Summary: | Title screen Background: Schizophrenia is a severe highly heritable mental disorder. The clinical heterogeneity of schizophrenia is expressed in the difference in the leading symptoms and course of the disease. Identifying the genetic variants that affect clinical heterogeneity may ultimately reveal the genetic basis of the features of schizophrenia and suggest novel treatment targets. PIP5K2A (Phosphatidylinositol-4-Phosphate 5-Kinase Type II Alpha) has been investigated as a potential susceptibility gene for schizophrenia. Methods: In this work, we studied the possible association between eleven polymorphic variants of PIP5K2A and the clinical features of schizophrenia in a population of 384 white Siberian patients with schizophrenia. Genotyping was carried out on QuantStudio 5 Real-Time PCR System with a TaqMan Validate SNP Genotyping Assay (Applied Biosystems, USA). Results: PIP5K2A rs8341 ([chi] 2 = 6.559, p = 0.038) and rs946961 ([chi] 2 = 5.976, p = 0.049) showed significant association with course of schizophrenia (continuous or episodic). The rs8341*CT (OR = 1.63, 95% CI: 1.04-2.54) and rs946961*CC (OR = 5.17, 95% CI: 1.20-22.21) genotypes were associated with a continuous type of course, while the rs8341*TT genotype (OR = 0.53, 95% CI: 0.29-0.97) was associated with an episodic type of course of schizophrenia. Therefore rs8341*TT genotype presumably has protective effect against the more severe continuous course of schizophrenia compared to the episodic one. Conclusions: Our experimental data confirm that PIP5K2A is a genetic factor influencing the type of course of schizophrenia in Siberian population. Disturbances in the phosphatidylinositol pathways may be a possible reason for the transition to a more severe continuous course of schizophrenia. |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12881-020-01107-w |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=665201 |
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| 200 | 1 | |a Genetic polymorphisms of PIP5K2A and course of schizophrenia |f E. Poltavskaya, O. Yu. Fedorenko, N. M. Vyalova [et al.] | |
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| 300 | |a Title screen | ||
| 320 | |a [References: 44 tit.] | ||
| 330 | |a Background: Schizophrenia is a severe highly heritable mental disorder. The clinical heterogeneity of schizophrenia is expressed in the difference in the leading symptoms and course of the disease. Identifying the genetic variants that affect clinical heterogeneity may ultimately reveal the genetic basis of the features of schizophrenia and suggest novel treatment targets. PIP5K2A (Phosphatidylinositol-4-Phosphate 5-Kinase Type II Alpha) has been investigated as a potential susceptibility gene for schizophrenia. Methods: In this work, we studied the possible association between eleven polymorphic variants of PIP5K2A and the clinical features of schizophrenia in a population of 384 white Siberian patients with schizophrenia. Genotyping was carried out on QuantStudio 5 Real-Time PCR System with a TaqMan Validate SNP Genotyping Assay (Applied Biosystems, USA). Results: PIP5K2A rs8341 ([chi] 2 = 6.559, p = 0.038) and rs946961 ([chi] 2 = 5.976, p = 0.049) showed significant association with course of schizophrenia (continuous or episodic). The rs8341*CT (OR = 1.63, 95% CI: 1.04-2.54) and rs946961*CC (OR = 5.17, 95% CI: 1.20-22.21) genotypes were associated with a continuous type of course, while the rs8341*TT genotype (OR = 0.53, 95% CI: 0.29-0.97) was associated with an episodic type of course of schizophrenia. Therefore rs8341*TT genotype presumably has protective effect against the more severe continuous course of schizophrenia compared to the episodic one. Conclusions: Our experimental data confirm that PIP5K2A is a genetic factor influencing the type of course of schizophrenia in Siberian population. Disturbances in the phosphatidylinositol pathways may be a possible reason for the transition to a more severe continuous course of schizophrenia. | ||
| 461 | |t BMC Medical Genetics | ||
| 463 | |t Vol. 21 |v [171, 9 p.] |d 2020 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a schizophrenia | |
| 610 | 1 | |a PIPK2A | |
| 610 | 1 | |a Genetic polymorphism | |
| 610 | 1 | |a Type of course | |
| 610 | 1 | |a Leading symptoms | |
| 610 | 1 | |a симптомы | |
| 610 | 1 | |a полиморфизм | |
| 610 | 1 | |a шизофрения | |
| 610 | 1 | |a психическое состояние | |
| 701 | 1 | |a Poltavskaya |b E. |g Evgeniya | |
| 701 | 1 | |a Fedorenko |b O. Yu. |c specialist in the field of ecology and life safety |c Professor of Tomsk Polytechnic University, doctor of medical sciences |f 1973- |g Olga Yurievna |3 (RuTPU)RU\TPU\pers\33861 |9 17450 | |
| 701 | 1 | |a Vyalova |b N. M. |g Nataljya Mikhaylovna | |
| 701 | 1 | |a Kornetova |b E. G. |g Elena Georgievna | |
| 701 | 1 | |a Bokhan |b N. A. |g Nikolay Aleksandrovich | |
| 701 | 1 | |a Loonen |b A. J. M |g Anton | |
| 701 | 1 | |a Ivanova |b S. A. |c specialist in the field of ecology and life safety |c Professor of Tomsk Polytechnic University, doctor of medical sciences |f 1964- |g Svetlana Aleksandrovna |3 (RuTPU)RU\TPU\pers\33859 | |
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