Variation in tumor pH affects pH-triggered delivery of peptide-modified magnetic nanoparticles

Variation in tumor pH affects pH-triggered delivery of peptide-modified magnetic nanoparticles

Bibliographic Details
Parent link:Nanomedicine: Nanotechnology, Biology and Medicine
Vol. 32.— 2021.— [102317, 13 p.]
Corporate Author: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Other Authors: Pershina A. G. Aleksandra Gennadievna, Brikunova O. Ya. Olga Yaroslavovna, Demin A. M. Aleksandr Mikhaylovich, Abakumov M. A. Maksim Artemovich, Vaneev A. N. Aleksandr Nikolaevich, Naumenko V. A. Viktor Alekseevich, Erofeev A. S. Aleksandr, Gorelik P. V. Pyotr, Nizamov T. R. Timur Radikovich, Muslimov A. R. Albert Radikovich, Timin A. S. Aleksandr Sergeevich, Malkeeva D. Dina, Kiseleva E. V. Elena Vladimirovna, Vtorushin S. V. Sergey Vladimirovich, Larionova I. V. Irina Valerievna
Summary:Title screen
Acidification of the extracellular matrix, an intrinsic characteristic of many solid tumors, is widely exploited for physiologically triggered delivery of contrast agents, drugs, and nanoparticles to tumor. However, pH of tumor microenvironment shows intra- and inter-tumor variation. Herein, we investigate the impact of this variation on pH-triggered delivery of magnetic nanoparticles (MNPs) modified with pH-(low)-insertion peptide (pHLIP). Fluorescent flow cytometry, laser confocal scanning microscopy and transmission electron microscopy data proved that pHLIP-conjugated MNPs interacted with 4T1 cells in two-dimensional culture and in spheroids more effectively at pH 6.4 than at pH 7.2, and entered the cell via clathrin-independent endocytosis. The accumulation efficiency of pHLIP-conjugated MNPs in 4T1 tumors after their intravenous injection, monitored in vivo by magnetic resonance imaging, showed variation. Analysis of the tumor pH profiles recorded with implementation of original nanoprobe pH sensor, revealed obvious correlation between pH measured in the tumor with the amount of accumulated MNPs.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2021
Subjects:
электронный ресурс
труды учёных ТПУ
iron oxide magnetic nanoparticles
pHLIP
endocytosis
MRIpH profile
магнитные наночастицы
эндоцитоз
оксид железа
опухоли
пептиды
Online Access:https://doi.org/10.1016/j.nano.2020.102317
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=665129

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