Variation in tumor pH affects pH-triggered delivery of peptide-modified magnetic nanoparticles; Nanomedicine: Nanotechnology, Biology and Medicine; Vol. 32
| Parent link: | Nanomedicine: Nanotechnology, Biology and Medicine Vol. 32.— 2021.— [102317, 13 p.] |
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| 団体著者: | |
| その他の著者: | , , , , , , , , , , , , , , |
| 要約: | Title screen Acidification of the extracellular matrix, an intrinsic characteristic of many solid tumors, is widely exploited for physiologically triggered delivery of contrast agents, drugs, and nanoparticles to tumor. However, pH of tumor microenvironment shows intra- and inter-tumor variation. Herein, we investigate the impact of this variation on pH-triggered delivery of magnetic nanoparticles (MNPs) modified with pH-(low)-insertion peptide (pHLIP). Fluorescent flow cytometry, laser confocal scanning microscopy and transmission electron microscopy data proved that pHLIP-conjugated MNPs interacted with 4T1 cells in two-dimensional culture and in spheroids more effectively at pH 6.4 than at pH 7.2, and entered the cell via clathrin-independent endocytosis. The accumulation efficiency of pHLIP-conjugated MNPs in 4T1 tumors after their intravenous injection, monitored in vivo by magnetic resonance imaging, showed variation. Analysis of the tumor pH profiles recorded with implementation of original nanoprobe pH sensor, revealed obvious correlation between pH measured in the tumor with the amount of accumulated MNPs. Режим доступа: по договору с организацией-держателем ресурса |
| 言語: | 英語 |
| 出版事項: |
2021
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| 主題: | |
| オンライン･アクセス: | https://doi.org/10.1016/j.nano.2020.102317 |
| フォーマット: | 電子媒体 図書の章 |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=665129 |
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| 200 | 1 | |a Variation in tumor pH affects pH-triggered delivery of peptide-modified magnetic nanoparticles |f A. G. Pershina, O. Ya. Brikunova, A. M. Demin [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 38 tit.] | ||
| 330 | |a Acidification of the extracellular matrix, an intrinsic characteristic of many solid tumors, is widely exploited for physiologically triggered delivery of contrast agents, drugs, and nanoparticles to tumor. However, pH of tumor microenvironment shows intra- and inter-tumor variation. Herein, we investigate the impact of this variation on pH-triggered delivery of magnetic nanoparticles (MNPs) modified with pH-(low)-insertion peptide (pHLIP). Fluorescent flow cytometry, laser confocal scanning microscopy and transmission electron microscopy data proved that pHLIP-conjugated MNPs interacted with 4T1 cells in two-dimensional culture and in spheroids more effectively at pH 6.4 than at pH 7.2, and entered the cell via clathrin-independent endocytosis. The accumulation efficiency of pHLIP-conjugated MNPs in 4T1 tumors after their intravenous injection, monitored in vivo by magnetic resonance imaging, showed variation. Analysis of the tumor pH profiles recorded with implementation of original nanoprobe pH sensor, revealed obvious correlation between pH measured in the tumor with the amount of accumulated MNPs. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Nanomedicine: Nanotechnology, Biology and Medicine | ||
| 463 | |t Vol. 32 |v [102317, 13 p.] |d 2021 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a iron oxide magnetic nanoparticles | |
| 610 | 1 | |a pHLIP | |
| 610 | 1 | |a endocytosis | |
| 610 | 1 | |a MRIpH profile | |
| 610 | 1 | |a магнитные наночастицы | |
| 610 | 1 | |a эндоцитоз | |
| 610 | 1 | |a оксид железа | |
| 610 | 1 | |a опухоли | |
| 610 | 1 | |a пептиды | |
| 701 | 1 | |a Pershina |b A. G. |c biologist |c Associate Professor of Tomsk Polytechnic University, Candidate of biological sciences |f 1981- |g Aleksandra Gennadievna |3 (RuTPU)RU\TPU\pers\32466 |9 16414 | |
| 701 | 1 | |a Brikunova |b O. Ya. |g Olga Yaroslavovna | |
| 701 | 1 | |a Demin |b A. M. |g Aleksandr Mikhaylovich | |
| 701 | 1 | |a Abakumov |b M. A. |g Maksim Artemovich | |
| 701 | 1 | |a Vaneev |b A. N. |g Aleksandr Nikolaevich | |
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| 701 | 1 | |a Muslimov |b A. R. |g Albert Radikovich | |
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| 701 | 1 | |a Vtorushin |b S. V. |g Sergey Vladimirovich | |
| 701 | 1 | |a Larionova |b I. V. |g Irina Valerievna | |
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