Hemolysis of Human Erythrocytes by Argovit™ AgNPs from Healthy and Diabetic Donors: An In Vitro Study; Materials; Vol. 14, iss. 11
| Parent link: | Materials Vol. 14, iss. 11.— 2021.— [2792, 12 p.] |
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| Autor Corporativo: | |
| Otros Autores: | , , , , , , , , |
| Sumario: | Title screen The use of nanomaterials is becoming increasingly widespread, leading to substantial research focused on nanomedicine. Nevertheless, the lack of complete toxicity profiles limits nanomaterials’ uses, despite their remarkable diagnostic and therapeutic results on in vitro and in vivo models. Silver nanoparticles (AgNPs), particularly Argovit™, have shown microbicidal, virucidal, and antitumoral effects. Among the first-line toxicity tests is the hemolysis assay. Here, the hemolytic effect of Argovit™ AgNPs on erythrocytes from one healthy donor (HDE) and one diabetic donor (DDE) is evaluated by the hemolysis assay against AgNO3. The results showed that Argovit™, in concentrations ?24 µg/mL of metallic silver, did not show a hemolytic effect on the HDE or DDE. On the contrary, AgNO3 at the same concentration of silver ions produces more than 10% hemolysis in both the erythrocyte types. In all the experimental conditions assessed, the DDE was shown to be more prone to hemolysis than the HDE elicited by Ag+ ions or AgNPs, but much more evident with Ag+ ions. The results show that Argovit™ is the least hemolytic compared with the other twenty-two AgNP formulations previously reported, probably due to the polymer mass used to stabilize the Argovit™ formulation. The results obtained provide relevant information that contributes to obtaining a comprehensive toxicological profile to design safe and effective AgNP formulations. |
| Lenguaje: | inglés |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://doi.org/10.3390/ma14112792 |
| Formato: | Electrónico Capítulo de libro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664988 |
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| 200 | 1 | |a Hemolysis of Human Erythrocytes by Argovit™ AgNPs from Healthy and Diabetic Donors: An In Vitro Study |f R. A. Luna-Vazquez-Gomez, M. E. Arellano-Garcia, J. C. Garcia-Ramos [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 61 tit.] | ||
| 330 | |a The use of nanomaterials is becoming increasingly widespread, leading to substantial research focused on nanomedicine. Nevertheless, the lack of complete toxicity profiles limits nanomaterials’ uses, despite their remarkable diagnostic and therapeutic results on in vitro and in vivo models. Silver nanoparticles (AgNPs), particularly Argovit™, have shown microbicidal, virucidal, and antitumoral effects. Among the first-line toxicity tests is the hemolysis assay. Here, the hemolytic effect of Argovit™ AgNPs on erythrocytes from one healthy donor (HDE) and one diabetic donor (DDE) is evaluated by the hemolysis assay against AgNO3. The results showed that Argovit™, in concentrations ?24 µg/mL of metallic silver, did not show a hemolytic effect on the HDE or DDE. On the contrary, AgNO3 at the same concentration of silver ions produces more than 10% hemolysis in both the erythrocyte types. In all the experimental conditions assessed, the DDE was shown to be more prone to hemolysis than the HDE elicited by Ag+ ions or AgNPs, but much more evident with Ag+ ions. The results show that Argovit™ is the least hemolytic compared with the other twenty-two AgNP formulations previously reported, probably due to the polymer mass used to stabilize the Argovit™ formulation. The results obtained provide relevant information that contributes to obtaining a comprehensive toxicological profile to design safe and effective AgNP formulations. | ||
| 461 | |t Materials | ||
| 463 | |t Vol. 14, iss. 11 |v [2792, 12 p.] |d 2021 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a in vitro hemolysis | |
| 610 | 1 | |a silver nanoparticles | |
| 610 | 1 | |a diabetic erythrocytes | |
| 610 | 1 | |a гемолиз | |
| 610 | 1 | |a наночастицы | |
| 610 | 1 | |a серебро | |
| 610 | 1 | |a эритроциты | |
| 701 | 1 | |a Luna-Vazquez-Gomez |b R. A. |g Roberto Anchel | |
| 701 | 1 | |a Arellano-Garcia |b M. E. |g Maria Evarista | |
| 701 | 1 | |a Garcia-Ramos |b J. C. |g Juan Carlos | |
| 701 | 1 | |a Radilla-Chavez |b P. |g Patricia | |
| 701 | 1 | |a Salas-Vargas |b D. S. |g David Sergio | |
| 701 | 1 | |a Casillas-Figueroa |b F. |g Francisco | |
| 701 | 1 | |a Ruiz-Ruiz |b B. |g Balam | |
| 701 | 1 | |a Bogdanchikova |b N. |g Nina | |
| 701 | 1 | |a Pestryakov |b A. N. |c Chemist |c Professor of Tomsk Polytechnic University, Doctor of Chemical Science |f 1963- |g Aleksey Nikolaevich |3 (RuTPU)RU\TPU\pers\30471 |9 14796 | |
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