Dual Targeting of Cancer Cells with DARPin-Based Toxins for Overcoming Tumor Escape; Cancers; Vol. 12, iss. 10

Dual Targeting of Cancer Cells with DARPin-Based Toxins for Overcoming Tumor Escape; Cancers; Vol. 12, iss. 10

Bibliografske podrobnosti
Parent link:Cancers
Vol. 12, iss. 10.— 2020.— [3014, 15 p.]
Korporativna značnica: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий Научно-исследовательский центр "Онкотераностика"
Drugi avtorji: Shramova E. I. Elena Ivanovna, Proshkina G. M. Galina Mikhaylovna, Shipunova V. Viktoriya, Ryabova A. Anastasiya, Kamyshinsky R. Roman, Konevega A. Andrey, Shulga (Schulga) A. A. Aleksey Anatolievich, Konovalova E. V. Elena Valerjevna, Telegin G. Georgy, Deev S. M. Sergey Mikhaylovich
Izvleček:Title screen
We report here a combined anti-cancer therapy directed toward HER2 and EpCAM, common tumor-associated antigens of breast cancer cells. The combined therapeutic effect is achieved owing to two highly toxic proteins—a low immunogenic variant of Pseudomonas aeruginosa exotoxin A and ribonuclease Barnase from Bacillus amyloliquefaciens. The delivery of toxins to cancer cells was carried out by targeting designed ankyrin repeat proteins (DARPins). We have shown that both target agents efficiently accumulate in the tumor. Simultaneous treatment of breast carcinoma-bearing mice with anti-EpCAM fusion toxin based on LoPE and HER2-specific liposomes loaded with Barnase leads to concurrent elimination of primary tumor and metastases. Monotherapy with anti-HER2- or anti-EpCAM-toxins did not produce a comparable effect on metastases. The proposed approach can be considered as a promising strategy for significant improvement of cancer therapy.
Jezik:angleščina
Izdano: 2020
Teme:
электронный ресурс
труды учёных ТПУ
barnase
liposomes
HER2
EpCAM
cancer therapy
липосомы
противораковая активность
терапия
Online dostop:https://doi.org/10.3390/cancers12103014
Format: Elektronski Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664919

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