Biodegradable Defined Shaped Printed Polymer Microcapsules for Drug Delivery

Biodegradable Defined Shaped Printed Polymer Microcapsules for Drug Delivery

Bibliographic Details
Parent link:ACS Applied Materials and Interfaces
Vol. 13, iss. 2.— 2021.— [P. 2371–2381]
Corporate Author: Национальный исследовательский Томский политехнический университет Инженерная школа ядерных технологий Научно-образовательный центр Б. П. Вейнберга
Other Authors: Kudryavtseva V. L. Valeriya Lvovna, Boi S. Stefania, Read J. E. Jordan, Guillemet R. Raphael, Zhang J. Jiaxin, Udalov A. A. Andrey Aleksandrovich, Shesterikov E. V. Evgeny Viktorovich, Tverdokhlebov S. I. Sergei Ivanovich, Pastorino L. Laura, Gould D. J. David, Sukhorukov G. B. Gleb Borisovich
Summary:Title screen
This work describes the preparation and characterization of printed biodegradable polymer (polylactic acid) capsules made in two different shapes: pyramid and rectangular capsules about 1 and 11 µm in size. Obtained core–shell capsules are described in terms of their morphology, loading efficiency, cargo release profile, cell cytotoxicity, and cell uptake. Both types of capsules showed monodisperse size and shape distribution and were found to provide sufficient stability to encapsulate small water-soluble molecules and to retain them for several days and ability for intracellular delivery. Capsules of 1 µm size can be internalized by HeLa cells without causing any toxicity effect. Printed capsules show unique characteristics compared with other drug delivery systems such as a wide range of possible cargoes, triggered release mechanism, and highly controllable shape and size.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2021
Subjects:
электронный ресурс
труды учёных ТПУ
drug delivery
polymer capsules
microprinting
polylactic acid
soft lithography
Online Access:https://doi.org/10.1021/acsami.0c21607
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664509

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