Surface characterization and biological assessment of corrosion-resistant a-C:H:SiOx PACVD coating for Ti-6Al-4V alloy; Materials Science and Engineering: C; Vol. 123

Surface characterization and biological assessment of corrosion-resistant a-C:H:SiOx PACVD coating for Ti-6Al-4V alloy; Materials Science and Engineering: C; Vol. 123

Dettagli Bibliografici
Parent link:Materials Science and Engineering: C
Vol. 123.— 2021.— [112002, 10 p.]
Ente Autore: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Altri autori: Grenaderov A. S. Aleksandr Sergeevich, Zhulkov M. O. Maksim Olegovich, Solovyev A. A., Oskomov K. V. Konstantin Vladimirovich, Semenov V. A., Chernyavskiy A. M. Aleksandr Mikhaylovich, Sirota D. A., Karmadonova N. A., Malashchenko V. V. Vladimir, Litvinova L. S., Khaziakhmatova O. G., Gazatova N. D., Khlusov I. A. Igor Albertovich
Riassunto:Title screen
The paper focuses on the SiOx-doped amorphous hydrocarbon (a-C:H:SiOx) coating on the titanium (Ti-6Al-4V) alloy substrate obtained by plasma-assisted chemical vapor deposition (PACVD) in a mixture of argon gas and polyphenylmethylsiloxane vapor using a bipolar substrate bias. It is shown that the a-C:H:SiOx coating deposition results in the formation of a negative surface potential important for application of this coating for medical implants. The a-C:H:SiOx coatings improve the corrosion resistance of Ti alloy to 0.5 M NaCl solution and phosphate-buffered saline. In particular, the corrosion current density of the a-C:H:SiOx-coated sample in a 0.5 M NaCl solution at 22 °C decreases from 1∙10−8 to 1.7∙10−10 A/cm2, that reduces the corrosion rate from 9∙10−5 to 15∙10−7 mm/year. The a-C:H:SiOx coating facilitates the surface endothelization of an implant located in the thoracic aorta of a mini pig, and reduces the risk of thrombosis and implant failure. This effect can be explained by the ability of the a-C:H:SiOx coating ability to reduce in vitro a 24-hour secretion of pro-inflammatory interleukins (IL-6, IL-12(p70), IL-15, and IL-17) and cytokines (IFN-g and TNF-a) by blood mononuclear cells (MNCs) and elevates the concentration of anti-inflammatory interleukin IL-1Ra. In vitro analysis shows no cytotoxicity of the a-C:H:SiOx coating for the human blood MNCs, suggesting a promising PACVD on Ti alloys for cardiovascular implants, including pumps for mechanical heart support systems.
Режим доступа: по договору с организацией-держателем ресурса
Lingua:inglese
Pubblicazione: 2021
Soggetti:
электронный ресурс
труды учёных ТПУ
PACVD
a-C:H:SiOx coating
corrosion resistance
cytotoxicity
коррозии
цитотоксичность
устойчивость
Accesso online:https://doi.org/10.1016/j.msec.2021.112002
Natura: MixedMaterials Elettronico Capitolo di libro
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664493

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