Surface characterization and biological assessment of corrosion-resistant a-C:H:SiOx PACVD coating for Ti-6Al-4V alloy; Materials Science and Engineering: C; Vol. 123
| Parent link: | Materials Science and Engineering: C Vol. 123.— 2021.— [112002, 10 p.] |
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| Institution som forfatter: | |
| Andre forfattere: | , , , , , , , , , , , , |
| Summary: | Title screen The paper focuses on the SiOx-doped amorphous hydrocarbon (a-C:H:SiOx) coating on the titanium (Ti-6Al-4V) alloy substrate obtained by plasma-assisted chemical vapor deposition (PACVD) in a mixture of argon gas and polyphenylmethylsiloxane vapor using a bipolar substrate bias. It is shown that the a-C:H:SiOx coating deposition results in the formation of a negative surface potential important for application of this coating for medical implants. The a-C:H:SiOx coatings improve the corrosion resistance of Ti alloy to 0.5 M NaCl solution and phosphate-buffered saline. In particular, the corrosion current density of the a-C:H:SiOx-coated sample in a 0.5 M NaCl solution at 22 °C decreases from 1∙10−8 to 1.7∙10−10 A/cm2, that reduces the corrosion rate from 9∙10−5 to 15∙10−7 mm/year. The a-C:H:SiOx coating facilitates the surface endothelization of an implant located in the thoracic aorta of a mini pig, and reduces the risk of thrombosis and implant failure. This effect can be explained by the ability of the a-C:H:SiOx coating ability to reduce in vitro a 24-hour secretion of pro-inflammatory interleukins (IL-6, IL-12(p70), IL-15, and IL-17) and cytokines (IFN-g and TNF-a) by blood mononuclear cells (MNCs) and elevates the concentration of anti-inflammatory interleukin IL-1Ra. In vitro analysis shows no cytotoxicity of the a-C:H:SiOx coating for the human blood MNCs, suggesting a promising PACVD on Ti alloys for cardiovascular implants, including pumps for mechanical heart support systems. Режим доступа: по договору с организацией-держателем ресурса |
| Sprog: | engelsk |
| Udgivet: |
2021
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| Fag: | |
| Online adgang: | https://doi.org/10.1016/j.msec.2021.112002 |
| Format: | Electronisk Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664493 |
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| 200 | 1 | |a Surface characterization and biological assessment of corrosion-resistant a-C:H:SiOx PACVD coating for Ti-6Al-4V alloy |f A. S. Grenaderov, M. O. Zhulkov, A. A. Solovyev [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 59 tit.] | ||
| 330 | |a The paper focuses on the SiOx-doped amorphous hydrocarbon (a-C:H:SiOx) coating on the titanium (Ti-6Al-4V) alloy substrate obtained by plasma-assisted chemical vapor deposition (PACVD) in a mixture of argon gas and polyphenylmethylsiloxane vapor using a bipolar substrate bias. It is shown that the a-C:H:SiOx coating deposition results in the formation of a negative surface potential important for application of this coating for medical implants. The a-C:H:SiOx coatings improve the corrosion resistance of Ti alloy to 0.5 M NaCl solution and phosphate-buffered saline. In particular, the corrosion current density of the a-C:H:SiOx-coated sample in a 0.5 M NaCl solution at 22 °C decreases from 1∙10−8 to 1.7∙10−10 A/cm2, that reduces the corrosion rate from 9∙10−5 to 15∙10−7 mm/year. The a-C:H:SiOx coating facilitates the surface endothelization of an implant located in the thoracic aorta of a mini pig, and reduces the risk of thrombosis and implant failure. This effect can be explained by the ability of the a-C:H:SiOx coating ability to reduce in vitro a 24-hour secretion of pro-inflammatory interleukins (IL-6, IL-12(p70), IL-15, and IL-17) and cytokines (IFN-g and TNF-a) by blood mononuclear cells (MNCs) and elevates the concentration of anti-inflammatory interleukin IL-1Ra. In vitro analysis shows no cytotoxicity of the a-C:H:SiOx coating for the human blood MNCs, suggesting a promising PACVD on Ti alloys for cardiovascular implants, including pumps for mechanical heart support systems. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Materials Science and Engineering: C | ||
| 463 | |t Vol. 123 |v [112002, 10 p.] |d 2021 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a PACVD | |
| 610 | 1 | |a a-C:H:SiOx coating | |
| 610 | 1 | |a corrosion resistance | |
| 610 | 1 | |a cytotoxicity | |
| 610 | 1 | |a коррозии | |
| 610 | 1 | |a цитотоксичность | |
| 610 | 1 | |a устойчивость | |
| 701 | 1 | |a Grenaderov |b A. S. |g Aleksandr Sergeevich | |
| 701 | 1 | |a Zhulkov |b M. O. |g Maksim Olegovich | |
| 701 | 1 | |a Solovyev |b A. A. | |
| 701 | 1 | |a Oskomov |b K. V. |g Konstantin Vladimirovich | |
| 701 | 1 | |a Semenov |b V. A. | |
| 701 | 1 | |a Chernyavskiy |b A. M. |g Aleksandr Mikhaylovich | |
| 701 | 1 | |a Sirota |b D. A. | |
| 701 | 1 | |a Karmadonova |b N. A. | |
| 701 | 1 | |a Malashchenko |b V. V. |g Vladimir | |
| 701 | 1 | |a Litvinova |b L. S. | |
| 701 | 1 | |a Khaziakhmatova |b O. G. | |
| 701 | 1 | |a Gazatova |b N. D. | |
| 701 | 1 | |a Khlusov |b I. A. |c biophysicist |c Professor of Tomsk Polytechnic University, doctor of medical Sciences |f 1963- |g Igor Albertovich |3 (RuTPU)RU\TPU\pers\34907 |9 18225 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Исследовательская школа химических и биомедицинских технологий |c (2017- ) |3 (RuTPU)RU\TPU\col\23537 |
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