Controlled drug release from electrospun PCL non-woven scaffolds via multi-layering and e-beam treatment; Materials Today Communications; Vol. 26

Controlled drug release from electrospun PCL non-woven scaffolds via multi-layering and e-beam treatment; Materials Today Communications; Vol. 26

Bibliografiske detaljer
Parent link:Materials Today Communications
Vol. 26.— 2021.— [102134, 13 p.]
Corporate Authors: Национальный исследовательский Томский политехнический университет Инженерная школа новых производственных технологий Научно-образовательный центр Н. М. Кижнера, Национальный исследовательский Томский политехнический университет Инженерная школа ядерных технологий Научно-образовательный центр Б. П. Вейнберга
Andre forfattere: Volokhova A. A. Apollinariya Aleksandrovna, Kudryavtseva V. L. Valeriya Lvovna, Spiridonova T. I. Tatjyana Igorevna, Kolesnik I. M. Iljya Maksimovich, Goreninsky (Goreninskii) S. I. Semen Igorevich, Sazonov R. V. Roman Vladimirovich, Remnev (Remnyov) G. E. Gennady Efimovich, Tverdokhlebov S. I. Sergei Ivanovich
Summary:Title screen
Currently, electrospun synthetic bioresorbable polymer scaffolds are applied in regenerative medicine and tissue engineering as targeted drug delivery devices because of their mechanical and physico-chemical properties. To control the rate of polymer degradation and drug release from polymer scaffolds, surface modification techniques are widely used. In this study, paracetamol-loaded poly (ε-caprolactone) electrospun fibrous scaffolds were treated by the pulsed electron beam irradiation. Pure control PCL scaffold, as well as scaffolds with four paracetamol concentrations (2 wt./wt. %, 8 wt./wt. %, 16 wt./wt. %, and 32 wt./wt.%) were modified. The mechanical and chemical properties and morphology of modified materials were examined. The sustained release of the model drug over a period of one hour for both non-treated and treated samples was demonstrated. It was shown that treatment leads to an increase in drug release rate and does not change surface morphology of scaffolds and fibers diameter distribution.
Режим доступа: по договору с организацией-держателем ресурса
Sprog:engelsk
Udgivet: 2021
Fag:
электронный ресурс
труды учёных ТПУ
drug delivery devices
electron beam treatment
biodegradable materials
polycaprolactone
electrospinning
доставка
лекарства
электронно-лучевая обработка
биоразлагаемые материалы
поликапролактон
электропрядение
Online adgang:https://doi.org/10.1016/j.mtcomm.2021.102134
Format: Electronisk Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664490

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