Controlled drug release from electrospun PCL non-woven scaffolds via multi-layering and e-beam treatment
| Parent link: | Materials Today Communications Vol. 26.— 2021.— [102134, 13 p.] |
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| Autor corporatiu: | , |
| Altres autors: | , , , , , , , |
| Sumari: | Title screen Currently, electrospun synthetic bioresorbable polymer scaffolds are applied in regenerative medicine and tissue engineering as targeted drug delivery devices because of their mechanical and physico-chemical properties. To control the rate of polymer degradation and drug release from polymer scaffolds, surface modification techniques are widely used. In this study, paracetamol-loaded poly (ε-caprolactone) electrospun fibrous scaffolds were treated by the pulsed electron beam irradiation. Pure control PCL scaffold, as well as scaffolds with four paracetamol concentrations (2 wt./wt. %, 8 wt./wt. %, 16 wt./wt. %, and 32 wt./wt.%) were modified. The mechanical and chemical properties and morphology of modified materials were examined. The sustained release of the model drug over a period of one hour for both non-treated and treated samples was demonstrated. It was shown that treatment leads to an increase in drug release rate and does not change surface morphology of scaffolds and fibers diameter distribution. Режим доступа: по договору с организацией-держателем ресурса |
| Idioma: | anglès |
| Publicat: |
2021
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| Matèries: | |
| Accés en línia: | https://doi.org/10.1016/j.mtcomm.2021.102134 |
| Format: | Electrònic Capítol de llibre |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664490 |
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| 200 | 1 | |a Controlled drug release from electrospun PCL non-woven scaffolds via multi-layering and e-beam treatment |f A. A. Volokhova, V. L. Kudryavtseva, T. I. Spiridonova [et al.] | |
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| 300 | |a Title screen | ||
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| 330 | |a Currently, electrospun synthetic bioresorbable polymer scaffolds are applied in regenerative medicine and tissue engineering as targeted drug delivery devices because of their mechanical and physico-chemical properties. To control the rate of polymer degradation and drug release from polymer scaffolds, surface modification techniques are widely used. In this study, paracetamol-loaded poly (ε-caprolactone) electrospun fibrous scaffolds were treated by the pulsed electron beam irradiation. Pure control PCL scaffold, as well as scaffolds with four paracetamol concentrations (2 wt./wt. %, 8 wt./wt. %, 16 wt./wt. %, and 32 wt./wt.%) were modified. The mechanical and chemical properties and morphology of modified materials were examined. The sustained release of the model drug over a period of one hour for both non-treated and treated samples was demonstrated. It was shown that treatment leads to an increase in drug release rate and does not change surface morphology of scaffolds and fibers diameter distribution. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Materials Today Communications | ||
| 463 | |t Vol. 26 |v [102134, 13 p.] |d 2021 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a drug delivery devices | |
| 610 | 1 | |a electron beam treatment | |
| 610 | 1 | |a biodegradable materials | |
| 610 | 1 | |a polycaprolactone | |
| 610 | 1 | |a electrospinning | |
| 610 | 1 | |a доставка | |
| 610 | 1 | |a лекарства | |
| 610 | 1 | |a электронно-лучевая обработка | |
| 610 | 1 | |a биоразлагаемые материалы | |
| 610 | 1 | |a поликапролактон | |
| 610 | 1 | |a электропрядение | |
| 701 | 1 | |a Volokhova |b A. A. |c specialist in the field of material science |c Engineer of Tomsk Polytechnic University |f 1995- |g Apollinariya Aleksandrovna |9 88476 | |
| 701 | 1 | |a Kudryavtseva |b V. L. |c physicist |c Engineer of Tomsk Polytechnic University |f 1993- |g Valeriya Lvovna |3 (RuTPU)RU\TPU\pers\38564 |9 20822 | |
| 701 | 1 | |a Spiridonova |b T. I. |c specialist in the field of material science |c Engineer of Tomsk Polytechnic University |f 1994- |g Tatjyana Igorevna |3 (RuTPU)RU\TPU\pers\43141 |9 21626 | |
| 701 | 1 | |a Kolesnik |b I. M. |g Iljya Maksimovich | |
| 701 | 1 | |a Goreninsky (Goreninskii) |b S. I. |c chemist |c engineer of Tomsk Polytechnic University |f 1993- |g Semen Igorevich |3 (RuTPU)RU\TPU\pers\40080 |9 21234 | |
| 701 | 1 | |a Sazonov |b R. V. |c physicist |c senior researcher of Tomsk Polytechnic University, candidate of physico-mathematical Sciences |f 1984- |g Roman Vladimirovich |3 (RuTPU)RU\TPU\pers\32698 |9 16584 | |
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