Bioinspired Spiky Peroxidase‐Mimics for Localized Bacterial Capture and Synergistic Catalytic Sterilization; Advanced Materials; Vol. 33, iss. 8

Bioinspired Spiky Peroxidase‐Mimics for Localized Bacterial Capture and Synergistic Catalytic Sterilization; Advanced Materials; Vol. 33, iss. 8

Dettagli Bibliografici
Parent link:Advanced Materials
Vol. 33, iss. 8.— 2021.— [2005477, 13 p.]
Ente Autore: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Altri autori: Yang Ye, Wu Xizheng, Ma Lang, He Chao, Cao Sujiao, Long Yanping, Huang Jianbo, Rodriguez (Rodriges) Contreras R. D. Raul David, Cheng Chong, Zhao Changsheng, Li Qiu
Riassunto:Title screen
Besides the pandemic caused by the coronavirus outbreak, many other pathogenic microbes also pose a devastating threat to human health, for instance, pathogenic bacteria. Due to the lack of broad‐spectrum antibiotics, it is urgent to develop nonantibiotic strategies to fight bacteria. Herein, inspired by the localized “capture and killing” action of bacteriophages, a virus‐like peroxidase‐mimic (V‐POD‐M) is synthesized for efficient bacterial capture (mesoporous spiky structures) and synergistic catalytic sterilization (metal-organic‐framework‐derived catalytic core). Experimental and theoretical calculations show that the active compound, MoO3, can serve as a peroxo‐complex‐intermediate to reduce the free energy for catalyzing H2O2, which mainly benefits the generation of •OH radicals. The unique virus‐like spikes endow the V‐POD‐M with fast bacterial capture and killing abilities (nearly 100% at 16 µg mL-1). Furthermore, the in vivo experiments show that V‐POD‐M possesses similar disinfection treatment and wound skin recovery efficiencies to vancomycin. It is suggested that this inexpensive, durable, and highly reactive oxygen species (ROS) catalytic active V‐POD‐M provides a promising broad‐spectrum therapy for nonantibiotic disinfection.
Lingua:inglese
Pubblicazione: 2021
Soggetti:
электронный ресурс
труды учёных ТПУ
bacterial capture
catalytic ROS generation
peroxidase-mimics and biomimetics
virus-like nanostructures
wound disinfection
бактериальная загрязненность
пероксидазы
биомиметика
имитаторы
дезинфекция
Accesso online:https://doi.org/10.1002/adma.202005477
Natura: Elettronico Capitolo di libro
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664473

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