Bioinspired Spiky Peroxidase‐Mimics for Localized Bacterial Capture and Synergistic Catalytic Sterilization; Advanced Materials; Vol. 33, iss. 8
| Parent link: | Advanced Materials Vol. 33, iss. 8.— 2021.— [2005477, 13 p.] |
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| 団体著者: | |
| その他の著者: | , , , , , , , , , , |
| 要約: | Title screen Besides the pandemic caused by the coronavirus outbreak, many other pathogenic microbes also pose a devastating threat to human health, for instance, pathogenic bacteria. Due to the lack of broad‐spectrum antibiotics, it is urgent to develop nonantibiotic strategies to fight bacteria. Herein, inspired by the localized “capture and killing” action of bacteriophages, a virus‐like peroxidase‐mimic (V‐POD‐M) is synthesized for efficient bacterial capture (mesoporous spiky structures) and synergistic catalytic sterilization (metal-organic‐framework‐derived catalytic core). Experimental and theoretical calculations show that the active compound, MoO3, can serve as a peroxo‐complex‐intermediate to reduce the free energy for catalyzing H2O2, which mainly benefits the generation of •OH radicals. The unique virus‐like spikes endow the V‐POD‐M with fast bacterial capture and killing abilities (nearly 100% at 16 µg mL-1). Furthermore, the in vivo experiments show that V‐POD‐M possesses similar disinfection treatment and wound skin recovery efficiencies to vancomycin. It is suggested that this inexpensive, durable, and highly reactive oxygen species (ROS) catalytic active V‐POD‐M provides a promising broad‐spectrum therapy for nonantibiotic disinfection. |
| 言語: | 英語 |
| 出版事項: |
2021
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| 主題: | |
| オンライン･アクセス: | https://doi.org/10.1002/adma.202005477 |
| フォーマット: | MixedMaterials 電子媒体 図書の章 |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664473 |
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| 200 | 1 | |a Bioinspired Spiky Peroxidase‐Mimics for Localized Bacterial Capture and Synergistic Catalytic Sterilization |f Yang Ye, Wu Xizheng, Ma Lang [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 58 tit.] | ||
| 330 | |a Besides the pandemic caused by the coronavirus outbreak, many other pathogenic microbes also pose a devastating threat to human health, for instance, pathogenic bacteria. Due to the lack of broad‐spectrum antibiotics, it is urgent to develop nonantibiotic strategies to fight bacteria. Herein, inspired by the localized “capture and killing” action of bacteriophages, a virus‐like peroxidase‐mimic (V‐POD‐M) is synthesized for efficient bacterial capture (mesoporous spiky structures) and synergistic catalytic sterilization (metal-organic‐framework‐derived catalytic core). Experimental and theoretical calculations show that the active compound, MoO3, can serve as a peroxo‐complex‐intermediate to reduce the free energy for catalyzing H2O2, which mainly benefits the generation of •OH radicals. The unique virus‐like spikes endow the V‐POD‐M with fast bacterial capture and killing abilities (nearly 100% at 16 µg mL-1). Furthermore, the in vivo experiments show that V‐POD‐M possesses similar disinfection treatment and wound skin recovery efficiencies to vancomycin. It is suggested that this inexpensive, durable, and highly reactive oxygen species (ROS) catalytic active V‐POD‐M provides a promising broad‐spectrum therapy for nonantibiotic disinfection. | ||
| 461 | |t Advanced Materials | ||
| 463 | |t Vol. 33, iss. 8 |v [2005477, 13 p.] |d 2021 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a bacterial capture | |
| 610 | 1 | |a catalytic ROS generation | |
| 610 | 1 | |a peroxidase-mimics and biomimetics | |
| 610 | 1 | |a virus-like nanostructures | |
| 610 | 1 | |a wound disinfection | |
| 610 | 1 | |a бактериальная загрязненность | |
| 610 | 1 | |a пероксидазы | |
| 610 | 1 | |a биомиметика | |
| 610 | 1 | |a имитаторы | |
| 610 | 1 | |a дезинфекция | |
| 701 | 1 | |a Yang Ye | |
| 701 | 0 | |a Wu Xizheng | |
| 701 | 0 | |a Ma Lang | |
| 701 | 0 | |a He Chao | |
| 701 | 0 | |a Cao Sujiao | |
| 701 | 0 | |a Long Yanping | |
| 701 | 0 | |a Huang Jianbo | |
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| 701 | 0 | |a Cheng Chong | |
| 701 | 0 | |a Zhao Changsheng | |
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| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Исследовательская школа химических и биомедицинских технологий |c (2017- ) |3 (RuTPU)RU\TPU\col\23537 |
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