Peptide Blocking CTLA-4 and B7-1 Interaction; Molecules; Vol. 26, iss. 2

Peptide Blocking CTLA-4 and B7-1 Interaction

Detalles Bibliográficos
Parent link:Molecules
Vol. 26, iss. 2.— 2021.— [252, 7 p.]
Autor Corporativo: Национальный исследовательский Томский политехнический университет Инженерная школа новых производственных технологий Научно-образовательный центр Н. М. Кижнера
Otros Autores: Podlesnykh S. V. Stepan Vasiljevich, Abramova K. E. Kristina Evgenjevna, Gordeeva A. Anastasiya, Khlebnikov A. I. Andrey Ivanovich, Chapoval A. I. Andrey Ivanovich
Sumario:Title screen
Discovery of the B7 family immune checkpoints such as CTLA-4 (CD152), PD-1 (CD279), as well as their ligands B7-1 (CD80), B7-2 (CD86), B7-H1 (PD-L1, CD274), and B7-DC (PD-L2, CD273), has opened new possibilities for cancer immunotherapy using monoclonal antibodies (mAb). The blockade of inhibitory receptors (CTLA-4 and PD-1) with specific mAb results in the activation of cancer patients’ T lymphocytes and tumor rejection. However, the use of mAb in clinics has several limitations including side effects and cost of treatment. The development of new low-molecular compounds that block immune checkpoints’ functional activity can help to overcome some of these limitations. In this paper, we describe a synthetic peptide (p344) containing 14 amino acids that specifically interact with CTLA-4 protein. A 3D computer model suggests that this peptide binds to the 99MYPPPY104 loop of CTLA-4 protein and potentially blocks the contact of CTLA-4 receptor with B7-1 ligand. Experimental data confirm the peptide-specific interaction with CTLA-4 and its ability to partially block CTLA-4/B7-1 binding. The identified synthetic peptide can be used for the development of novel immune checkpoint inhibitors that can block CTLA-4 functional activity for cancer immunotherapy.
Lenguaje:inglés
Publicado: 2021
Materias:
труды учёных ТПУ
электронный ресурс
peptides
immune checkpoints
peptide microarray
cancer
immunotherapy
пептиды
микрочипы
иммунотерапия
рак
Acceso en línea:https://doi.org/10.3390/molecules26020253
Formato: Electrónico Capítulo de libro
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664433

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