Layer-by-Layer technique as a versatile tool for gene delivery applications; Expert Opinion on Drug Delivery; Vol. XX, iss. X

Layer-by-Layer technique as a versatile tool for gene delivery applications; Expert Opinion on Drug Delivery; Vol. XX, iss. X

Bibliographic Details
Parent link:Expert Opinion on Drug Delivery
Vol. XX, iss. X.— 2021.— [P. 1-19]
Corporate Author: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Other Authors: Linnik D. S. Dmitrii Sergeevich, Tarakanchikova Ya. V. Yana Vladimirovna, Zyuzin M. V. Mikhail, Lepik K. V., Aerts J. L. Joeri, Sukhorukov G. Gleb, Timin A. S. Aleksandr Sergeevich
Summary:Title screen
Introduction: Gene therapy is a breakthrough medical field which focuses on the therapeutic delivery of recombinant nucleic acids in order to treat or prevent a broad spectrum of diseases. However, a number of important obstacles remain before its wide introduction into clinical practice can be envisaged. One of the biggest bottlenecks is the lack of efficient and safe delivery technologies, particularly, for in vivo distribution. Above and beyond standard requirements for carriers, the delivery systems for gene therapy ideally use a hit-and-run principle (to minimize off-target effect and display of immunogenic moieties). None of the currently used viral vectors fulfills all of these requirements. Therefore, the growing variety of non-viral delivery platforms represents a promising alternative. Areas covered: This review summarizes the Layer-by-Layer (LbL) approaches that can be effectively used for the gene delivery, considering various examples with the transfer of pDNA, mRNA, siRNA as well as genome-editing tools. Ex vivo gene modification of clinically relevant cells and clinical aspects for possible application of LbL systems in gene therapy are also underlined. Expert opinion: The LbL technique provides broad opportunities for the delivery of genetic material for various purposes and offers promise for future clinical application in gene therapy.
Language:English
Published: 2021
Subjects:
электронный ресурс
труды учёных ТПУ
layer-by-layer
templates
multilayer capsules
gene delivery
RNA
DNA
ex vivo cell modification
clinical perspective
слои
Online Access:https://doi.org/10.1080/17425247.2021.1879790
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664360

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