Radiolabeling Strategies of Micron- and Submicron-Sized Core–Shell Carriers for In Vivo Studies

Radiolabeling Strategies of Micron- and Submicron-Sized Core–Shell Carriers for In Vivo Studies

Bibliographic Details
Parent link:ACS Applied Materials and Interfaces
Vol. 12, iss. 28.— 2020.— [P. 31137–31147]
Corporate Author: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Other Authors: Zyuzin M. V. Mikhail, Antuganov D. Dmitrii, Tarakanchikova Ya. V. Yana Vladimirovna, Karpov T. E. Timofey Evgenjevich, Mashel T. V. Tatiana Vladimirovna, Gerasimova E. N. Elena Nikolaevna, Peltek A. O. Aleksey Olekseevich, Nomine A. Alexandre, Bruyere S. Stephanie, Kondratenko Yu. A. Yulia Andreevna, Muslimov A. R. Albert, Timin A. S. Aleksandr Sergeevich
Summary:Title screen
Two-dimensional (2D) transition-metal dichalcogenides have become promising candidates for surface-enhanced Raman spectroscopy (SERS), but currently very few examples of detection of relevant molecules are available. Herein, we show the detection of the lipophilic disease marker ?-sitosterol on few-layered MoTe2 films. The chemical vapor deposition (CVD)-grown films are capable of nanomolar detection, exceeding the performance of alternative noble-metal surfaces. We confirm that the enhancement occurs through the chemical enhancement (CE) mechanism via formation of a surface–analyte complex, which leads to an enhancement factor of ?104, as confirmed by Fourier transform infrared (FTIR), UV–vis, and cyclic voltammetry (CV) analyses and density functional theory (DFT) calculations. Low values of signal deviation over a seven-layered MoTe2 film confirms the homogeneity and reproducibility of the results in comparison to noble-metal substrate analogues. Furthermore, ?-sitosterol detection within cell culture media, a minimal loss of signal over 50 days, and the opportunity for sensor regeneration suggest that MoTe2 can become a promising new SERS platform for biosensing.
Режим доступа: по договору с организацией-держателем ресурса
Published: 2020
Subjects:
электронный ресурс
труды учёных ТПУ
Layer-by-Layer
calcium carbonate
core-shell particles
nuclear imaging technique
radiolabeling
PET
biodistribution
Online Access:https://doi.org/10.1021/acsami.0c06996
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664330

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