Polysaccharides based microspheres for multiple encapsulations and simultaneous release of proteases

Polysaccharides based microspheres for multiple encapsulations and simultaneous release of proteases

Bibliografiska uppgifter
Parent link:International Journal of Biological Macromolecules
Vol. 132.— 2019.— [P. 24-31]
Institutionell upphovsman: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий (ИШХБМТ)
Övriga upphovsmän: Ozaltin K. Kadir, Postnikov P. S. Pavel Sergeevich, Trusova M. E. Marina Evgenievna, Sedlarik V. Vladimir, Di Martino A. Antonio
Sammanfattning:Title screen
The work is focused on the development of microspheres based on the combination of two polysaccharides; chitosan and alginic acid with the aim to allocate, hold, release and protect environmentally sensible molecules. The microspheres were prepared using a solvent-free, low cost and scalable approach and two enzymes; trypsin and protease from Aspergillus Oryzae have been used as a model to evaluate the microspheres peculiarities. The proteins were encapsulated during the microspheres preparation. The relationship between the polysaccharides weight ratio and the morphology, stability and ability of the carrier to allocate the enzymes has been evaluated. The enzymatic activity and the release kinetics were assessed in different conditions to assess the impact of the external environment. Obtained results demonstrate the efficacy of the prepared microspheres to preserve the activity of relevant bioactive compounds which are highly relevant in food, cosmetic and pharmaceutic, but the application is limited due to their high sensibility.
Режим доступа: по договору с организацией-держателем ресурса
Publicerad: 2019
Ämnen:
электронный ресурс
труды учёных ТПУ
microencapsulation
microspheres
polysaccharides
protease
controlled delivery
микрокапсулирование
микросферы
полисахариды
биоактивные соединения
Länkar:https://doi.org/10.1016/j.ijbiomac.2019.03.189
Materialtyp: Elektronisk Bokavsnitt
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664301

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