Polysaccharides based microspheres for multiple encapsulations and simultaneous release of proteases; International Journal of Biological Macromolecules; Vol. 132
| Parent link: | International Journal of Biological Macromolecules Vol. 132.— 2019.— [P. 24-31] |
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| Ente Autore: | |
| Altri autori: | , , , , |
| Riassunto: | Title screen The work is focused on the development of microspheres based on the combination of two polysaccharides; chitosan and alginic acid with the aim to allocate, hold, release and protect environmentally sensible molecules. The microspheres were prepared using a solvent-free, low cost and scalable approach and two enzymes; trypsin and protease from Aspergillus Oryzae have been used as a model to evaluate the microspheres peculiarities. The proteins were encapsulated during the microspheres preparation. The relationship between the polysaccharides weight ratio and the morphology, stability and ability of the carrier to allocate the enzymes has been evaluated. The enzymatic activity and the release kinetics were assessed in different conditions to assess the impact of the external environment. Obtained results demonstrate the efficacy of the prepared microspheres to preserve the activity of relevant bioactive compounds which are highly relevant in food, cosmetic and pharmaceutic, but the application is limited due to their high sensibility. Режим доступа: по договору с организацией-держателем ресурса |
| Lingua: | inglese |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://doi.org/10.1016/j.ijbiomac.2019.03.189 |
| Natura: | Elettronico Capitolo di libro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664301 |
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| 200 | 1 | |a Polysaccharides based microspheres for multiple encapsulations and simultaneous release of proteases |f K. Ozaltin, P. S. Postnikov, M. E. Trusova [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 34 tit.] | ||
| 330 | |a The work is focused on the development of microspheres based on the combination of two polysaccharides; chitosan and alginic acid with the aim to allocate, hold, release and protect environmentally sensible molecules. The microspheres were prepared using a solvent-free, low cost and scalable approach and two enzymes; trypsin and protease from Aspergillus Oryzae have been used as a model to evaluate the microspheres peculiarities. The proteins were encapsulated during the microspheres preparation. The relationship between the polysaccharides weight ratio and the morphology, stability and ability of the carrier to allocate the enzymes has been evaluated. The enzymatic activity and the release kinetics were assessed in different conditions to assess the impact of the external environment. Obtained results demonstrate the efficacy of the prepared microspheres to preserve the activity of relevant bioactive compounds which are highly relevant in food, cosmetic and pharmaceutic, but the application is limited due to their high sensibility. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t International Journal of Biological Macromolecules | ||
| 463 | |t Vol. 132 |v [P. 24-31] |d 2019 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a microencapsulation | |
| 610 | 1 | |a microspheres | |
| 610 | 1 | |a polysaccharides | |
| 610 | 1 | |a protease | |
| 610 | 1 | |a controlled delivery | |
| 610 | 1 | |a микрокапсулирование | |
| 610 | 1 | |a микросферы | |
| 610 | 1 | |a полисахариды | |
| 610 | 1 | |a биоактивные соединения | |
| 701 | 1 | |a Ozaltin |b K. |g Kadir | |
| 701 | 1 | |a Postnikov |b P. S. |c organic chemist |c Associate Professor of Tomsk Polytechnic University, Candidate of chemical sciences |f 1984- |g Pavel Sergeevich |3 (RuTPU)RU\TPU\pers\31287 |9 15465 | |
| 701 | 1 | |a Trusova |b M. E. |c organic chemist |c Associate professor of Tomsk Polytechnic University, Candidate of chemical sciences |f 1982- |g Marina Evgenievna |3 (RuTPU)RU\TPU\pers\31823 |9 15918 | |
| 701 | 1 | |a Sedlarik |b V. |g Vladimir | |
| 701 | 1 | |a Di Martino |b A. |c organic chemist |c research of Tomsk Polytechnic University |f 1984- |g Antonio |9 20983 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Исследовательская школа химических и биомедицинских технологий (ИШХБМТ) |c (2017- ) |3 (RuTPU)RU\TPU\col\23537 |
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