Chelidonic Acid and Its Derivatives from Saussurea Controversa: Isolation, Structural Elucidation and Influence on the Osteogenic Differentiation of Multipotent Mesenchymal Stromal Cells In Vitro; Biomolecules; Vol. 9, iss. 5
| Parent link: | Biomolecules Vol. 9, iss. 5.— 2019.— [189, 12 p.] |
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| Müşterek Yazar: | |
| Diğer Yazarlar: | , , , , , , , , , , , |
| Özet: | 4-oxo-4H-pyran-2.6-dicarboxylic acid (chelidonic acid, ChA) in the native state and in the complex with calcium [Ca(ChA)(H2O)3], named saucalchelin (CaChA), was isolated from the extract of Saussurea controversa leaves for the first time for the Asteraceae family. The structure of ChA was determined by NMR, MS and confirmed by X-ray analysis of its monomethyl ester, and CaChA was described by IR, ICP-MS, CHN analysis. The yield of ChA and CaChA was 45 mg/g and 70 mg/g of extract, respectively. The osteogenic activity of ChA, n-monobutyl ester of chelidonic acid, and CaChA has been studied in vitro in a 21-day culture of human adipose-derived multipotent mesenchymal stromal cells (hAMMSCs) in a standard nutrient medium without osteogenic supplements. CaChA significantly stimulated the growth of cell mass and differentiation of hAMMSCs into osteoblasts with subsequent mineralization of the culture and it may be a promising substance for accelerating bone tissue regeneration and engineering. Режим доступа: по договору с организацией-держателем ресурса |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
2019
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| Konular: | |
| Online Erişim: | https://doi.org/10.3390/biom9050189 |
| Materyal Türü: | Elektronik Kitap Bölümü |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664284 |
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| 200 | 1 | |a Chelidonic Acid and Its Derivatives from Saussurea Controversa: Isolation, Structural Elucidation and Influence on the Osteogenic Differentiation of Multipotent Mesenchymal Stromal Cells In Vitro |f E. Avdeeva, E. Shults, T. Rybalova [et al.] | |
| 203 | |a Text |c electronic | ||
| 320 | |a [References: 29 tit.] | ||
| 330 | |a 4-oxo-4H-pyran-2.6-dicarboxylic acid (chelidonic acid, ChA) in the native state and in the complex with calcium [Ca(ChA)(H2O)3], named saucalchelin (CaChA), was isolated from the extract of Saussurea controversa leaves for the first time for the Asteraceae family. The structure of ChA was determined by NMR, MS and confirmed by X-ray analysis of its monomethyl ester, and CaChA was described by IR, ICP-MS, CHN analysis. The yield of ChA and CaChA was 45 mg/g and 70 mg/g of extract, respectively. The osteogenic activity of ChA, n-monobutyl ester of chelidonic acid, and CaChA has been studied in vitro in a 21-day culture of human adipose-derived multipotent mesenchymal stromal cells (hAMMSCs) in a standard nutrient medium without osteogenic supplements. CaChA significantly stimulated the growth of cell mass and differentiation of hAMMSCs into osteoblasts with subsequent mineralization of the culture and it may be a promising substance for accelerating bone tissue regeneration and engineering. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Biomolecules | ||
| 463 | |t Vol. 9, iss. 5 |v [189, 12 p.] |d 2019 | ||
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a 4-oxo-4H-pyran-2.6-dicarboxylic acid esters | |
| 610 | 1 | |a Saussurea controversa DC (Asteraceae) | |
| 610 | 1 | |a X-ray diffraction analysis | |
| 610 | 1 | |a chelidonic acid | |
| 610 | 1 | |a human multipotent mesenchymal stromal cells | |
| 610 | 1 | |a сложные эфиры | |
| 610 | 1 | |a рентгеноструктурный анализ | |
| 610 | 1 | |a хелидоновая кислота | |
| 701 | 1 | |a Avdeeva |b E. |g Elena | |
| 701 | 1 | |a Shults |b E. |g Elvira | |
| 701 | 1 | |a Rybalova |b T. |g Tatyana | |
| 701 | 1 | |a Reshetov |b Ya. E. |g Yaroslav Evgenjevich | |
| 701 | 1 | |a Porokhova |b E. |g Ekaterina | |
| 701 | 1 | |a Sukhodolo |b I. |g Irina | |
| 701 | 1 | |a Litvinova |b L. S. | |
| 701 | 1 | |a Shupletsova |b V. V. |g Valeria | |
| 701 | 1 | |a Khaziakhmatova |b O. G. | |
| 701 | 1 | |a Khlusov |b I. A. |c biophysicist |c Professor of Tomsk Polytechnic University, doctor of medical Sciences |f 1963- |g Igor Albertovich |3 (RuTPU)RU\TPU\pers\34907 |9 18225 | |
| 701 | 1 | |a Gurjev |b A. M. |g Artem Mikhaylovich | |
| 701 | 1 | |a Belousov |b M. V. |c chemist |c Professor of Tomsk Polytechnic University, Doctor of Pharmaceutical Sciences |f 1963- |g Mikhail Valerievich |3 (RuTPU)RU\TPU\pers\45418 |9 21924 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Исследовательская школа химических и биомедицинских технологий |c (2017- ) |3 (RuTPU)RU\TPU\col\23537 |
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