Nuclear nanomedicine using Si nanoparticles as safe and effective carriers of 188Re radionuclide for cancer therapy; Scientific Reports; Vol. 9
| Parent link: | Scientific Reports Vol. 9.— 2019.— [2017, 10 p.] |
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| 団体著者: | |
| その他の著者: | , , , , , , , , , , , , |
| 要約: | Title screen Nuclear nanomedicine, with its targeting ability and heavily loading capacity, along with its enhanced retention to avoid rapid clearance as faced with molecular radiopharmaceuticals, provides unique opportunities to treat tumors and metastasis. Despite these promises, this field has seen limited activities, primarily because of a lack of suitable nanocarriers, which are safe, excretable and have favorable pharmacokinetics to efficiently deliver and retain radionuclides in a tumor. Here, we introduce biodegradable laser-synthesized Si nanoparticles having round shape, controllable low-dispersion size, and being free of any toxic impurities, as highly suitable carriers of therapeutic 188Re radionuclide. The conjugation of the polyethylene glycol-coated Si nanoparticles with radioactive 188Re takes merely 1?hour, compared to its half-life of 17?hours. When intravenously administered in a Wistar rat model, the conjugates demonstrate free circulation in the blood stream to reach all organs and target tumors, which is radically in contrast with that of the 188Re salt that mostly accumulates in the thyroid gland. We also show that the nanoparticles ensure excellent retention of 188Re in tumor, not possible with the salt, which enables one to maximize the therapeutic effect, as well as exhibit a complete time-delayed conjugate bioelimination. Finally, our tests on rat survival demonstrate excellent therapeutic effect (72% survival compared to 0% of the control group). Combined with a series of imaging and therapeutic functionalities based on unique intrinsic properties of Si nanoparticles, the proposed biodegradable complex promises a major advancement in nuclear nanomedicine. |
| 言語: | 英語 |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://doi.org/10.1038/s41598-018-38474-7 |
| フォーマット: | 電子媒体 図書の章 |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664226 |
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| 200 | 1 | |a Nuclear nanomedicine using Si nanoparticles as safe and effective carriers of 188Re radionuclide for cancer therapy |f V. M. Petriev, V. K. Tishchenko, A. A. Mikhaylovskaya [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 26 tit.] | ||
| 330 | |a Nuclear nanomedicine, with its targeting ability and heavily loading capacity, along with its enhanced retention to avoid rapid clearance as faced with molecular radiopharmaceuticals, provides unique opportunities to treat tumors and metastasis. Despite these promises, this field has seen limited activities, primarily because of a lack of suitable nanocarriers, which are safe, excretable and have favorable pharmacokinetics to efficiently deliver and retain radionuclides in a tumor. Here, we introduce biodegradable laser-synthesized Si nanoparticles having round shape, controllable low-dispersion size, and being free of any toxic impurities, as highly suitable carriers of therapeutic 188Re radionuclide. The conjugation of the polyethylene glycol-coated Si nanoparticles with radioactive 188Re takes merely 1?hour, compared to its half-life of 17?hours. When intravenously administered in a Wistar rat model, the conjugates demonstrate free circulation in the blood stream to reach all organs and target tumors, which is radically in contrast with that of the 188Re salt that mostly accumulates in the thyroid gland. We also show that the nanoparticles ensure excellent retention of 188Re in tumor, not possible with the salt, which enables one to maximize the therapeutic effect, as well as exhibit a complete time-delayed conjugate bioelimination. Finally, our tests on rat survival demonstrate excellent therapeutic effect (72% survival compared to 0% of the control group). Combined with a series of imaging and therapeutic functionalities based on unique intrinsic properties of Si nanoparticles, the proposed biodegradable complex promises a major advancement in nuclear nanomedicine. | ||
| 461 | |t Scientific Reports | ||
| 463 | |t Vol. 9 |v [2017, 10 p.] |d 2019 | ||
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| 701 | 1 | |a Petriev |b V. M. |g Vasily Mikhaylovich | |
| 701 | 1 | |a Tishchenko |b V. K. | |
| 701 | 1 | |a Mikhaylovskaya |b A. A. |g Anastasiya Aleksandrovna | |
| 701 | 1 | |a Popov |b A. A. | |
| 701 | 1 | |a Tselikov |b G. |g Gleb | |
| 701 | 1 | |a Zelepukin |b I. V. |g Ivan Vladimirovich | |
| 701 | 1 | |a Deev |b S. M. |c biologist |c Leading Researcher, Tomsk Polytechnic University, Doctor of Biological Sciences |f 1951- |g Sergey Mikhaylovich |3 (RuTPU)RU\TPU\pers\39299 | |
| 701 | 1 | |a Kaprin |b A. D. |g Andrey Dmitrievich | |
| 701 | 1 | |a Ivanov |b S. | |
| 701 | 1 | |a Timoshenko |b V. Yu. |g Viktor Yurjevich | |
| 701 | 1 | |a Prasad |b P. N. | |
| 701 | 1 | |a Zavestovskaya |b N. I. |g Nina Iljinichna | |
| 701 | 1 | |a Kabashin |b A. V. |g Andrey Viktorovich | |
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