HER2-Specific Targeted Toxin DARPin-LoPE: Immunogenicity and Antitumor Effect on Intraperitoneal Ovarian Cancer Xenograft Model; International Journal of Molecular Sciences; Vol. 20, iss. 10

HER2-Specific Targeted Toxin DARPin-LoPE: Immunogenicity and Antitumor Effect on Intraperitoneal Ovarian Cancer Xenograft Model; International Journal of Molecular Sciences; Vol. 20, iss. 10

Bibliographic Details
Parent link:International Journal of Molecular Sciences
Vol. 20, iss. 10.— 2019.— [2399, 19 p. ]
Corporate Author: Национальный исследовательский Томский политехнический университет Физико-технический институт Лаборатория № 31 ядерного реактора
Other Authors: Sokolova E. A. Evgeniya Aleksandrovna, Shilova O. N. Olga Nikolaevna, Kiselyova D. V. Darjya Vladimirovna, Shulga A. A. Aleksey Anatolievich, Balalaeva I. V. Irina Vladimirovna, Deev S. M. Sergey Mikhaylovich
Summary:Title screen
High immunogenicity and systemic toxicity are the main obstacles limiting the clinical use of the therapeutic agents based on Pseudomonas aeruginosa exotoxin A. In this work, we studied the immunogenicity, general toxicity and antitumor effect of the targeted toxin DARPin-LoPE composed of HER2-specific DARPin and a low immunogenic exotoxin A fragment lacking immunodominant human B lymphocyte epitopes. The targeted toxin has been shown to effectively inhibit the growth of HER2-positive human ovarian carcinoma xenografts, while exhibiting low non-specific toxicity and side effects, such as vascular leak syndrome and liver tissue degradation, as well as low immunogenicity, as was shown by specific antibody titer. This represents prospects for its use as an agent for targeted therapy of HER2-positive tumors.
Language:English
Published: 2019
Subjects:
труды учёных ТПУ
электронный ресурс
targeted therapy
DARPin
Pseudomonas exotoxin A
immunogenicity
ovarian carcinoma
HER2
far-red fluorescent protein
терапия
рак
Online Access:https://doi.org/10.3390/ijms20102399
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664213

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