C-Jun N-Terminal Kinases and Their Pharmacological Modulation in Ischemic and Reperfusion Brain Injury; Neuroscience and Behavioral Physiology; Vol. 48, iss. 6
| Parent link: | Neuroscience and Behavioral Physiology.— , 1967- Vol. 48, iss. 6.— 2019.— [P. 721–728] |
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| Autor Corporativo: | |
| Outros autores: | , , , |
| Summary: | Title screen We present here a review of the literature on the role of c-Jun N-terminal kinases (JNK) and their inhibitors in ischemic and reperfusion brain injuries. The functions of JNK in the signal mechanisms involved in brain damage in ischemia and reperfusion are discussed. Effects linked with inhibition of JNK with synthetic and natural compounds in experimental models of ischemia and reperfusion brain injury are described. Results from experimental studies show that JNK provide potential therapeutic targets for protecting the brain from ischemic stroke. However, the fact that JNK have numerous physiological functions prevents systematic use of nonspecific inhibitors of these kinases for therapeutic purposes. The authors conclude that this task requires a further search for selective JNK3 inhibitors. Режим доступа: по договору с организацией-держателем ресурса |
| Idioma: | inglés |
| Publicado: |
2019
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| Subjects: | |
| Acceso en liña: | https://doi.org/10.1007/s11055-018-0622-4 |
| Formato: | Electrónico Capítulo de libro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664088 |
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| 200 | 1 | |a c-Jun N-Terminal Kinases and Their Pharmacological Modulation in Ischemic and Reperfusion Brain Injury |f M. V. Shvedova, Ya. J. Anfinogenova, I. A. Schepetkin (Shchepyotkin), D. N. Atochin | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 86 tit.] | ||
| 330 | |a We present here a review of the literature on the role of c-Jun N-terminal kinases (JNK) and their inhibitors in ischemic and reperfusion brain injuries. The functions of JNK in the signal mechanisms involved in brain damage in ischemia and reperfusion are discussed. Effects linked with inhibition of JNK with synthetic and natural compounds in experimental models of ischemia and reperfusion brain injury are described. Results from experimental studies show that JNK provide potential therapeutic targets for protecting the brain from ischemic stroke. However, the fact that JNK have numerous physiological functions prevents systematic use of nonspecific inhibitors of these kinases for therapeutic purposes. The authors conclude that this task requires a further search for selective JNK3 inhibitors. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Neuroscience and Behavioral Physiology |d 1967- | ||
| 463 | |t Vol. 48, iss. 6 |v [P. 721–728] |d 2019 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a c-Jun N-terminal kinase | |
| 610 | 1 | |a JNK inhibitor | |
| 610 | 1 | |a stroke | |
| 610 | 1 | |a ischemic-reperfusion injury | |
| 610 | 1 | |a brain | |
| 610 | 1 | |a therapeutic target | |
| 701 | 1 | |a Shvedova |b M. V. |g Mariya Vitaljevna | |
| 701 | 1 | |a Anfinogenova |b Ya. J. |c Linguist |c Lecturer of Tomsk Polytechnic University, Doctor of medical sciences |f 1970- |g Yana Jonovna |3 (RuTPU)RU\TPU\pers\33592 | |
| 701 | 1 | |a Schepetkin (Shchepyotkin) |b I. A. |c doctor-biophysicist |c leading researcher of Tomsk Polytechnic University, candidate of medical science |f 1962- |g Igor Aleksandrovich |3 (RuTPU)RU\TPU\pers\37358 | |
| 701 | 1 | |a Atochin |b D. N. |g Dmitry Nikolaevich | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Инженерная школа новых производственных технологий |b Научно-образовательный центр Н. М. Кижнера |3 (RuTPU)RU\TPU\col\23556 |
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