Electrosprayed poly(lactic-co-glycolic acid) particles as a promising drug delivery system for the novel JNK inhibitor IQ-1

Electrosprayed poly(lactic-co-glycolic acid) particles as a promising drug delivery system for the novel JNK inhibitor IQ-1

Détails bibliographiques
Parent link:European Polymer Journal
Vol. 127.— 2020.— [109598, 9 p.]
Collectivité auteur: Национальный исследовательский Томский политехнический университет Исследовательская школа физики высокоэнергетических процессов
Autres auteurs: Kibler E. V. Elina Vitaljevna, Lavrinenko A. K. Anastasiya Konstantinovna, Kolesnik I. M. Iljya Maksimovich, Stankevich K. S. Ksenia Sergeevna, Bolbasov E. N. Evgeny Nikolaevich, Kudryavtseva V. L. Valeriya Lvovna, Leonov A. A. Andrey Andreevich, Schepetkin (Shchepyotkin) I. A. Igor Aleksandrovich, Khlebnikov A. I. Andrey Ivanovich, Quinn M. T. Mark, Tverdokhlebov S. I. Sergei Ivanovich
Résumé:Title screen
Mitogen-activated protein kinases (MAPKs), including c-Jun N-terminal kinase (JNK), play important role in the regulation of pro-inflammatory cytokine secretion and signaling cascades. Therefore, JNKs are key targets for the treatment of cytokine/JNK-driven diseases. Herein, we developed electrospray poly(lactic-co-glycolic acid) (PLGA) microparticles doped with novel JNK inhibitor 11H-indeno[1,2-b]quinoxalin-11-one oxime (IQ-1). Optimized electrospray parameters allowed us to produce IQ-1-doped microparticles with round shape, smooth and non-porous surface, and mean diameter of 0.9-1.3 μm. We have shown that IQ-1 was well integrated into the polymer matrix and had a prolonged release in two steps via non-Fickian release. The fabricated particles doped with IQ-1 exhibited anti-inflammatory effects, as indicated by inhibited neutrophil activation and cytokine secretion by human monocytic MonoMac-6 cells. Overall, our study demonstrates that PLGA microparticles doped with a novel JNK inhibitor (IQ-1) could be a promising delivery system for treatment of JNK-mediated diseases.
Режим доступа: по договору с организацией-держателем ресурса
Langue:anglais
Publié: 2020
Sujets:
электронный ресурс
труды учёных ТПУ
electrospray
drug delivery
poly(lactic-co-glycolic acid)
c-Jun N-terminal kinase inhibitor
электрораспыление
Accès en ligne:https://doi.org/10.1016/j.eurpolymj.2020.109598
Format: Électronique Chapitre de livre
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664065

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