Electrosprayed poly(lactic-co-glycolic acid) particles as a promising drug delivery system for the novel JNK inhibitor IQ-1; European Polymer Journal; Vol. 127
| Parent link: | European Polymer Journal Vol. 127.— 2020.— [109598, 9 p.] |
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| Údar corparáideach: | |
| Rannpháirtithe: | , , , , , , , , , , |
| Achoimre: | Title screen Mitogen-activated protein kinases (MAPKs), including c-Jun N-terminal kinase (JNK), play important role in the regulation of pro-inflammatory cytokine secretion and signaling cascades. Therefore, JNKs are key targets for the treatment of cytokine/JNK-driven diseases. Herein, we developed electrospray poly(lactic-co-glycolic acid) (PLGA) microparticles doped with novel JNK inhibitor 11H-indeno[1,2-b]quinoxalin-11-one oxime (IQ-1). Optimized electrospray parameters allowed us to produce IQ-1-doped microparticles with round shape, smooth and non-porous surface, and mean diameter of 0.9-1.3 μm. We have shown that IQ-1 was well integrated into the polymer matrix and had a prolonged release in two steps via non-Fickian release. The fabricated particles doped with IQ-1 exhibited anti-inflammatory effects, as indicated by inhibited neutrophil activation and cytokine secretion by human monocytic MonoMac-6 cells. Overall, our study demonstrates that PLGA microparticles doped with a novel JNK inhibitor (IQ-1) could be a promising delivery system for treatment of JNK-mediated diseases. Режим доступа: по договору с организацией-держателем ресурса |
| Teanga: | Béarla |
| Foilsithe / Cruthaithe: |
2020
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| Ábhair: | |
| Rochtain ar líne: | https://doi.org/10.1016/j.eurpolymj.2020.109598 |
| Formáid: | Leictreonach Caibidil leabhair |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664065 |
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| 200 | 1 | |a Electrosprayed poly(lactic-co-glycolic acid) particles as a promising drug delivery system for the novel JNK inhibitor IQ-1 |f E. V. Kibler, A. K. Lavrinenko, I. M. Kolesnik [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 67 tit.] | ||
| 330 | |a Mitogen-activated protein kinases (MAPKs), including c-Jun N-terminal kinase (JNK), play important role in the regulation of pro-inflammatory cytokine secretion and signaling cascades. Therefore, JNKs are key targets for the treatment of cytokine/JNK-driven diseases. Herein, we developed electrospray poly(lactic-co-glycolic acid) (PLGA) microparticles doped with novel JNK inhibitor 11H-indeno[1,2-b]quinoxalin-11-one oxime (IQ-1). Optimized electrospray parameters allowed us to produce IQ-1-doped microparticles with round shape, smooth and non-porous surface, and mean diameter of 0.9-1.3 μm. We have shown that IQ-1 was well integrated into the polymer matrix and had a prolonged release in two steps via non-Fickian release. The fabricated particles doped with IQ-1 exhibited anti-inflammatory effects, as indicated by inhibited neutrophil activation and cytokine secretion by human monocytic MonoMac-6 cells. Overall, our study demonstrates that PLGA microparticles doped with a novel JNK inhibitor (IQ-1) could be a promising delivery system for treatment of JNK-mediated diseases. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t European Polymer Journal | ||
| 463 | |t Vol. 127 |v [109598, 9 p.] |d 2020 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a electrospray | |
| 610 | 1 | |a drug delivery | |
| 610 | 1 | |a poly(lactic-co-glycolic acid) | |
| 610 | 1 | |a c-Jun N-terminal kinase inhibitor | |
| 610 | 1 | |a электрораспыление | |
| 701 | 1 | |a Kibler |b E. V. |c specialist in the field of nuclear technologies |c Engineer of Tomsk Polytechnic University |f 1995- |g Elina Vitaljevna |3 (RuTPU)RU\TPU\pers\46672 | |
| 701 | 1 | |a Lavrinenko |b A. K. |g Anastasiya Konstantinovna | |
| 701 | 1 | |a Kolesnik |b I. M. |g Iljya Maksimovich | |
| 701 | 1 | |a Stankevich |b K. S. |c Physicist |c Engineer Tomsk Polytechnic University |f 1992- |g Ksenia Sergeevna |3 (RuTPU)RU\TPU\pers\37546 | |
| 701 | 1 | |a Bolbasov |b E. N. |c physicist |c Senior Researcher at Tomsk Polytechnic University, Candidate of Technical Sciences |f 1981- |g Evgeny Nikolaevich |3 (RuTPU)RU\TPU\pers\30857 |9 15103 | |
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