Association between 8 P‐glycoprotein (MDR1/ABCB1) gene polymorphisms and antipsychotic drug‐induced hyperprolactinaemia; British Journal of Clinical Pharmacology; Vol. 86, iss. 9

Association between 8 P‐glycoprotein (MDR1/ABCB1) gene polymorphisms and antipsychotic drug‐induced hyperprolactinaemia; British Journal of Clinical Pharmacology; Vol. 86, iss. 9

Bibliografiske detaljer
Parent link:British Journal of Clinical Pharmacology
Vol. 86, iss. 9.— 2020.— [P. 1827-1835]
Institution som forfatter: Национальный исследовательский Томский политехнический университет Инженерная школа неразрушающего контроля и безопасности Отделение контроля и диагностики
Andre forfattere: Geers L. M., Pozhidaev I. V. Ivan, Ivanova S. A. Svetlana Aleksandrovna, Freydin M. B. Maksim Borisovich, Schmidt A. F. Amand, Cohen D., Boyko A. S., Paderina D. Z. Diana, Fedorenko O. Yu. Olga Yurievna, Semke A. V., Bokhan N. A. Nikolay Aleksandrovich, Wilffert B. Bob, Kosterink J. G.W. Jos, Touw D. J., Loonen A. J. M Anton
Summary:Title screen
Hyperprolactinaemia, a common adverse effect of antipsychotic drugs, is primarily linked to blockade of dopamine D2 receptors in the pituitary gland. Certain antipsychotic drugs, such as, for example risperidone and paliperidone, are more likely to induce hyperprolactinaemia compared to others. This effect is probably caused by a relatively high blood/brain concentration ratio, a consequence of being a substrate of P‐glycoprotein. Genetic variants of P‐glycoprotein with changed functional activity might influence the potential of risperidone and paliperidone to cause hyperprolactinaemia as the altered blood/brain concentration ratio would lead to a reduced therapeutic drug level within essential brain areas making dose adaptations necessary. This increases exposure of dopamine D2 receptors within the pituitary gland.
Режим доступа: по договору с организацией-держателем ресурса
Sprog:engelsk
Udgivet: 2020
Fag:
электронный ресурс
труды учёных ТПУ
antipsychotics
hyperprolactinaemia
MDR1/ABCB1 gene
P-glycoprotein
polymorphisms
Online adgang:https://doi.org/10.1111/bcpt.13173
Format: MixedMaterials Electronisk Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664042

Lignende værker

Lignende værker