Controllable Synthesis of Calcium Carbonate with Different Geometry: Comprehensive Analysis of Particle Formation, Cellular Uptake, and Biocompatibility
| Parent link: | ACS Sustainable Chemistry and Engineering Vol. 7, No. 23.— 2019.— [P. 19142–19156] |
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| מחבר תאגידי: | |
| מחברים אחרים: | , , , , , , , , , , , , , |
| סיכום: | Title screen Carefully designed micro- and nanocarriers can provide significant advantages over conventional macroscopic counterparts in drug delivery applications. For the successful delivery of bioactive compounds, carriers should possess a high loading capacity, triggered release mechanisms, biocompatibility, and biodegradability. Porous calcium carbonate (CaCO3) is one of the most promising platforms, which can encompass all the aforementioned requirements. Here, we study both the formation of particles and the biological applicability of CaCO3. In particular, differently shaped anisotropic CaCO3 particles are synthesized using a sustainable and green approach based on coprecipitation of calcium chloride and sodium carbonate/bicarbonate at different ratios in the presence of organic additives. The impact of salt concentrations, reaction time, and organic additives are systematically investigated to achieve a controllable and reliable design of CaCO3 particles. It is demonstrated that the crystallinity (vaterite or calcite phase) of particles depends on the initial salt concentrations. The loading capacity of prepared CaCO3 particles is determined by their surface properties such as specific surface area, pore size, and zeta-potential. Differently shaped CaCO3 particles (spheroids, ellipsoids, and toroids) are exploited, and their uptake efficiency on an example of C6 glioma cells is evaluated. The results show that ellipsoidal particles are more likely to be internalized by cancer cells. All the particles tested are also found to have good biocompatibility. The ability to design physicochemical properties of CaCO3 particles has a significant impact on drug delivery applications since particle geometry substantially affects cell behavior (internalization and toxicity). Режим доступа: по договору с организацией-держателем ресурса |
| יצא לאור: |
2019
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| נושאים: | |
| גישה מקוונת: | https://doi.org/10.1021/acssuschemeng.9b05128 |
| פורמט: | אלקטרוני Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=663974 |
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| 200 | 1 | |a Controllable Synthesis of Calcium Carbonate with Different Geometry: Comprehensive Analysis of Particle Formation, Cellular Uptake, and Biocompatibility |f H. Barhom, A. A. Goncharenko, L. Khafutdinov [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 330 | |a Carefully designed micro- and nanocarriers can provide significant advantages over conventional macroscopic counterparts in drug delivery applications. For the successful delivery of bioactive compounds, carriers should possess a high loading capacity, triggered release mechanisms, biocompatibility, and biodegradability. Porous calcium carbonate (CaCO3) is one of the most promising platforms, which can encompass all the aforementioned requirements. Here, we study both the formation of particles and the biological applicability of CaCO3. In particular, differently shaped anisotropic CaCO3 particles are synthesized using a sustainable and green approach based on coprecipitation of calcium chloride and sodium carbonate/bicarbonate at different ratios in the presence of organic additives. The impact of salt concentrations, reaction time, and organic additives are systematically investigated to achieve a controllable and reliable design of CaCO3 particles. It is demonstrated that the crystallinity (vaterite or calcite phase) of particles depends on the initial salt concentrations. The loading capacity of prepared CaCO3 particles is determined by their surface properties such as specific surface area, pore size, and zeta-potential. Differently shaped CaCO3 particles (spheroids, ellipsoids, and toroids) are exploited, and their uptake efficiency on an example of C6 glioma cells is evaluated. The results show that ellipsoidal particles are more likely to be internalized by cancer cells. All the particles tested are also found to have good biocompatibility. The ability to design physicochemical properties of CaCO3 particles has a significant impact on drug delivery applications since particle geometry substantially affects cell behavior (internalization and toxicity). | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t ACS Sustainable Chemistry and Engineering | ||
| 463 | |t Vol. 7, No. 23 |v [P. 19142–19156] |d 2019 | ||
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a calcium carbonate | |
| 610 | 1 | |a formation mechanisms | |
| 610 | 1 | |a drug carriers | |
| 610 | 1 | |a adsorption | |
| 610 | 1 | |a cell uptake | |
| 610 | 1 | |a toxicity | |
| 610 | 1 | |a карбонат кальция | |
| 610 | 1 | |a адсорбция | |
| 610 | 1 | |a токсичность | |
| 701 | 1 | |a Barhom |b H. |g Hani | |
| 701 | 1 | |a Goncharenko |b A. A. |g Aleksandr Aleksandrovich | |
| 701 | 1 | |a Khafutdinov |b L. |g Landysh | |
| 701 | 1 | |a Peltek |b A. O. |g Aleksey Olekseevich | |
| 701 | 1 | |a Muslimov |b A. R. |g Albert Radikovich | |
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| 701 | 1 | |a Noskov |b R. E. |g Roman | |
| 701 | 1 | |a Timin |b A. S. |c Chemist |c Associate Scientist of Tomsk Polytechnic University |f 1989- |g Aleksandr Sergeevich |3 (RuTPU)RU\TPU\pers\37036 | |
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| 701 | 1 | |a Zyuzin |b M. V. |g Mikhail | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Исследовательская школа химических и биомедицинских технологий |c (2017- ) |3 (RuTPU)RU\TPU\col\23537 |
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