Development of Optimized Strategies for Growth Factor Incorporation onto Electrospun Fibrous Scaffolds To Promote Prolonged Release; ACS Applied Materials and Interfaces; Vol. 12, iss. 5

Development of Optimized Strategies for Growth Factor Incorporation onto Electrospun Fibrous Scaffolds To Promote Prolonged Release; ACS Applied Materials and Interfaces; Vol. 12, iss. 5

Bibliografski detalji
Parent link:ACS Applied Materials and Interfaces
Vol. 12, iss. 5.— 2020.— [P. 5578-5592]
Autori kompanije: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий, Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий Научно-исследовательский центр "Физическое материаловедение и композитные материалы"
Daljnji autori: Karpov T. E. Timofey Evgenjevich, Peltek A. O. Aleksey Olekseevich, Muslimov A. R. Albert Radikovich, Tarakanchikova Ya. V. Yana Vladimirovna, Grunina T. M. Tatjyana, Popova M. S. Mariya Sergeevna, Karyagina A. S. Anna, Chernozem R. V. Roman Viktorovich, Pary (Pariy) I. O. Igor Olegovich, Mukhortova Yu. R. Yulia Ruslanovna, Zhukov M. V. Mikhail Valerjevich, Surmeneva M. A. Maria Alexandrovna, Zyuzin M. V. Mikhail, Timin A. S. Aleksandr Sergeevich, Surmenev R. A. Roman Anatolievich
Sažetak:Title screen
Growth factor incorporation in biomedical constructs for their local delivery enables specific pharmacological effects such as the induction of cell growth and differentiation. This has enabled a promising way to improve the tissue regeneration process. However, it remains challenging to identify an appropriate approach that provides effective growth factor loading into biomedical constructs with their following release kinetics in a prolonged manner. In the present work, we performed a systematic study, which explores the optimal strategy of growth factor incorporation into sub-micrometric-sized CaCO3 core–shell particles (CSPs) and hollow silica particles (SiPs). These carriers were immobilized onto the surface of the polymer scaffolds based on polyhydroxybutyrate (PHB) with and without reduced graphene oxide (rGO) in its structure to examine the functionality of incorporated growth factors. Bone morphogenetic protein-2 (BMP-2) and ErythroPOietin (EPO) as growth factor models were included into CSPs and SiPs using different entrapping strategies, namely, physical adsorption, coprecipitation technique, and freezing-induced loading method. It was shown that the loading efficiency, release characteristics, and bioactivity of incorporated growth factors strongly depend on the chosen strategy of their incorporation into delivery systems. Overall, we demonstrated that the combination of scaffolds with drug delivery systems containing growth factors has great potential in the field of tissue regeneration compared with individual scaffolds.
Режим доступа: по договору с организацией-держателем ресурса
Jezik:engleski
Izdano: 2020
Teme:
электронный ресурс
труды учёных ТПУ
tissue regeneration
3D polymer scaffolds
reduced graphene oxide
core-shell particles
hollow silica particles
growth factors
cell behavior
osteogenic differentiation
Online pristup:https://doi.org/10.1021/acsami.9b20697
Format: Elektronički Poglavlje knjige
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=663902

Internet

https://doi.org/10.1021/acsami.9b20697

Slični predmeti