Supporting data and methods for the characterization of iron oxide nanoparticles conjugated with pH-(low)-insertion peptide, testing their cytotoxicity and analyses of biodistribution in SCID mice bearing MDA-MB231 tumor

Supporting data and methods for the characterization of iron oxide nanoparticles conjugated with pH-(low)-insertion peptide, testing their cytotoxicity and analyses of biodistribution in SCID mice bearing MDA-MB231 tumor

Opis bibliograficzny
Parent link:Data in Brief
Vol. 29.— 2020.— [105062, 15 p.]
Korporacja: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Kolejni autorzy: Pershina A. G. Aleksandra Gennadievna, Brikunova O. Ya. Olga Yaroslavovna, Perekucha N. A. Nataljya Andreevna, Demin A. M. Aleksandr Mikhaylovich, Shevelev O. B. Oleg Borisovich, Malkeeva D. Dina, Kiseleva E. V. Elena Vladimirovna, Minin A. S., Kostikova L. A. Larisa Anatolyevna, Stepanov I. V. Ivan Vadimovich, Kuznetsov D. K. Dmitrii Konstantinovich, Shur V. Ya. Vladimir Yakovlevich, Krasnov V. P. Viktor Pavlovich
Streszczenie:Title screen
The method of Fe3O4 magnetic nanoparticle synthesis by co-precipitation, modification by 3-aminopropylsilane and conjugation with pH-(low)-insertion peptide (pHLIP) is reported. The characterization of nanoparticles by scanning electron microscopy, transmission electron microscopy, Fourier-transform infrared spectroscopy, elemental and thermogravimetric analyses as well as dynamic light scattering and z-potential measurements is provided. The effect of nanoparticles on the viability of mouse and human peripheral blood mononuclear cells is tested by flow cytometry. The experimental details of nanoparticle administration to tumor-bearing mice, magnetic resonance imaging scanning as well as subsequent tumor sample collection and their processing for transmission electron microscopy, inductively coupled plasma atomic emission spectroscopy, histological and immunohistochemical analyses are described. Biodistribution of the nanoparticles in mice and blood serum analysis data for experimental animals are given. The data are useful for an experiment workflow design and for the development of theranostic systems based on magnetic nanoparticles.
Режим доступа: по договору с организацией-держателем ресурса
Język:angielski
Wydane: 2020
Hasła przedmiotowe:
электронный ресурс
труды учёных ТПУ
pHLIP
iron oxide magnetic nanoparticle
nanoparticle characterization
tumor
biodistribution
cytotoxicity
наночастицы
опухоли
цитотоксичность
Dostęp online:https://doi.org/10.1016/j.dib.2019.105062
Format: Elektroniczne Rozdział
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=663774

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