Supporting data and methods for the characterization of iron oxide nanoparticles conjugated with pH-(low)-insertion peptide, testing their cytotoxicity and analyses of biodistribution in SCID mice bearing MDA-MB231 tumor; Data in Brief; Vol. 29
| Parent link: | Data in Brief Vol. 29.— 2020.— [105062, 15 p.] |
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| Autor Corporativo: | |
| Outros autores: | , , , , , , , , , , , , |
| Summary: | Title screen The method of Fe3O4 magnetic nanoparticle synthesis by co-precipitation, modification by 3-aminopropylsilane and conjugation with pH-(low)-insertion peptide (pHLIP) is reported. The characterization of nanoparticles by scanning electron microscopy, transmission electron microscopy, Fourier-transform infrared spectroscopy, elemental and thermogravimetric analyses as well as dynamic light scattering and z-potential measurements is provided. The effect of nanoparticles on the viability of mouse and human peripheral blood mononuclear cells is tested by flow cytometry. The experimental details of nanoparticle administration to tumor-bearing mice, magnetic resonance imaging scanning as well as subsequent tumor sample collection and their processing for transmission electron microscopy, inductively coupled plasma atomic emission spectroscopy, histological and immunohistochemical analyses are described. Biodistribution of the nanoparticles in mice and blood serum analysis data for experimental animals are given. The data are useful for an experiment workflow design and for the development of theranostic systems based on magnetic nanoparticles. Режим доступа: по договору с организацией-держателем ресурса |
| Idioma: | inglés |
| Publicado: |
2020
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| Subjects: | |
| Acceso en liña: | https://doi.org/10.1016/j.dib.2019.105062 |
| Formato: | Electrónico Capítulo de libro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=663774 |
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| 200 | 1 | |a Supporting data and methods for the characterization of iron oxide nanoparticles conjugated with pH-(low)-insertion peptide, testing their cytotoxicity and analyses of biodistribution in SCID mice bearing MDA-MB231 tumor |f A. G. Pershina, O. Ya. Brikunova, N. A. Perekucha [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 9 tit.] | ||
| 330 | |a The method of Fe3O4 magnetic nanoparticle synthesis by co-precipitation, modification by 3-aminopropylsilane and conjugation with pH-(low)-insertion peptide (pHLIP) is reported. The characterization of nanoparticles by scanning electron microscopy, transmission electron microscopy, Fourier-transform infrared spectroscopy, elemental and thermogravimetric analyses as well as dynamic light scattering and z-potential measurements is provided. The effect of nanoparticles on the viability of mouse and human peripheral blood mononuclear cells is tested by flow cytometry. The experimental details of nanoparticle administration to tumor-bearing mice, magnetic resonance imaging scanning as well as subsequent tumor sample collection and their processing for transmission electron microscopy, inductively coupled plasma atomic emission spectroscopy, histological and immunohistochemical analyses are described. Biodistribution of the nanoparticles in mice and blood serum analysis data for experimental animals are given. The data are useful for an experiment workflow design and for the development of theranostic systems based on magnetic nanoparticles. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Data in Brief | ||
| 463 | |t Vol. 29 |v [105062, 15 p.] |d 2020 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a pHLIP | |
| 610 | 1 | |a iron oxide magnetic nanoparticle | |
| 610 | 1 | |a nanoparticle characterization | |
| 610 | 1 | |a tumor | |
| 610 | 1 | |a biodistribution | |
| 610 | 1 | |a cytotoxicity | |
| 610 | 1 | |a наночастицы | |
| 610 | 1 | |a опухоли | |
| 610 | 1 | |a цитотоксичность | |
| 701 | 1 | |a Pershina |b A. G. |c biologist |c Associate Professor of Tomsk Polytechnic University, Candidate of biological sciences |f 1981- |g Aleksandra Gennadievna |3 (RuTPU)RU\TPU\pers\32466 |9 16414 | |
| 701 | 1 | |a Brikunova |b O. Ya. |g Olga Yaroslavovna | |
| 701 | 1 | |a Perekucha |b N. A. |g Nataljya Andreevna | |
| 701 | 1 | |a Demin |b A. M. |g Aleksandr Mikhaylovich | |
| 701 | 1 | |a Shevelev |b O. B. |g Oleg Borisovich | |
| 701 | 1 | |a Malkeeva |b D. |g Dina | |
| 701 | 1 | |a Kiseleva |b E. V. |g Elena Vladimirovna | |
| 701 | 1 | |a Minin |b A. S. | |
| 701 | 1 | |a Kostikova |b L. A. |c Chemical engineer |c Engineer of Tomsk Polytechnic University |f 1974- |g Larisa Anatolyevna |3 (RuTPU)RU\TPU\pers\42438 | |
| 701 | 1 | |a Stepanov |b I. V. |g Ivan Vadimovich | |
| 701 | 1 | |a Kuznetsov |b D. K. |g Dmitrii Konstantinovich | |
| 701 | 1 | |a Shur |b V. Ya. |g Vladimir Yakovlevich | |
| 701 | 1 | |a Krasnov |b V. P. |g Viktor Pavlovich | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Исследовательская школа химических и биомедицинских технологий |c (2017- ) |3 (RuTPU)RU\TPU\col\23537 |
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