Current outlook on radionuclide delivery systems: from design consideration to translation into clinics

Current outlook on radionuclide delivery systems: from design consideration to translation into clinics

Bibliographische Detailangaben
Parent link:Journal of Nanobiotechnology
Vol. 17, iss. 1.— 2020.— [90, 34 p.]
Körperschaft: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Weitere Verfasser: Peltek A. O. Aleksey Olekseevich, Muslimov A. R. Albert Radikovich, Zyuzin M. V. Mikhail, Timin A. S. Aleksandr Sergeevich
Zusammenfassung:Title screen
Radiopharmaceuticals have proven to be effective agents, since they can be successfully applied for both diagnostics and therapy. Effective application of relevant radionuclides in pre-clinical and clinical studies depends on the choice of a sufficient delivery platform. Herein, we provide a comprehensive review on the most relevant aspects in radionuclide delivery using the most employed carrier systems, including, (i) monoclonal antibodies and their fragments, (ii) organic and (iii) inorganic nanoparticles, and (iv) microspheres. This review offers an extensive analysis of radionuclide delivery systems, the approaches of their modification and radiolabeling strategies with the further prospects of their implementation in multimodal imaging and disease curing. Finally, the comparative outlook on the carriers and radionuclide choice, as well as on the targeting efficiency of the developed systems is discussed.
Sprache:Englisch
Veröffentlicht: 2020
Schlagworte:
электронный ресурс
труды учёных ТПУ
nuclear medicine
diagnostic and therapeutic radionuclides
drug carrier systems
monoclonal antibodies
manoparticles
microspheres
radiopharmaceuticals
theranostics
multimodal imaging
Online-Zugang:https://doi.org/10.1186/s12951-019-0524-9
https://doi.org/10.1186/s12951-019-0558-z
http://earchive.tpu.ru/handle/11683/64872
Format: Elektronisch Buchkapitel
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=663746

Ähnliche Einträge

Ähnliche Einträge