Current outlook on radionuclide delivery systems: from design consideration to translation into clinics; Journal of Nanobiotechnology; Vol. 17, iss. 1
| Источник: | Journal of Nanobiotechnology Vol. 17, iss. 1.— 2020.— [90, 34 p.] |
|---|---|
| Автор-организация: | |
| Другие авторы: | , , , |
| Примечания: | Title screen Radiopharmaceuticals have proven to be effective agents, since they can be successfully applied for both diagnostics and therapy. Effective application of relevant radionuclides in pre-clinical and clinical studies depends on the choice of a sufficient delivery platform. Herein, we provide a comprehensive review on the most relevant aspects in radionuclide delivery using the most employed carrier systems, including, (i) monoclonal antibodies and their fragments, (ii) organic and (iii) inorganic nanoparticles, and (iv) microspheres. This review offers an extensive analysis of radionuclide delivery systems, the approaches of their modification and radiolabeling strategies with the further prospects of their implementation in multimodal imaging and disease curing. Finally, the comparative outlook on the carriers and radionuclide choice, as well as on the targeting efficiency of the developed systems is discussed. |
| Язык: | английский |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://doi.org/10.1186/s12951-019-0524-9 https://doi.org/10.1186/s12951-019-0558-z http://earchive.tpu.ru/handle/11683/64872 |
| Формат: | Электронный ресурс Статья |
| Запись в KOHA: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=663746 |
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| 200 | 1 | |a Current outlook on radionuclide delivery systems: from design consideration to translation into clinics |f A. O. Peltek, A. R. Muslimov, M. V. Zyuzin, A. S. Timin | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 255 tit.] | ||
| 330 | |a Radiopharmaceuticals have proven to be effective agents, since they can be successfully applied for both diagnostics and therapy. Effective application of relevant radionuclides in pre-clinical and clinical studies depends on the choice of a sufficient delivery platform. Herein, we provide a comprehensive review on the most relevant aspects in radionuclide delivery using the most employed carrier systems, including, (i) monoclonal antibodies and their fragments, (ii) organic and (iii) inorganic nanoparticles, and (iv) microspheres. This review offers an extensive analysis of radionuclide delivery systems, the approaches of their modification and radiolabeling strategies with the further prospects of their implementation in multimodal imaging and disease curing. Finally, the comparative outlook on the carriers and radionuclide choice, as well as on the targeting efficiency of the developed systems is discussed. | ||
| 461 | |t Journal of Nanobiotechnology | ||
| 463 | |t Vol. 17, iss. 1 |v [90, 34 p.] |d 2020 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a nuclear medicine | |
| 610 | 1 | |a diagnostic and therapeutic radionuclides | |
| 610 | 1 | |a drug carrier systems | |
| 610 | 1 | |a monoclonal antibodies | |
| 610 | 1 | |a manoparticles | |
| 610 | 1 | |a microspheres | |
| 610 | 1 | |a radiopharmaceuticals | |
| 610 | 1 | |a theranostics | |
| 610 | 1 | |a multimodal imaging | |
| 701 | 1 | |a Peltek |b A. O. |g Aleksey Olekseevich | |
| 701 | 1 | |a Muslimov |b A. R. |g Albert Radikovich | |
| 701 | 1 | |a Zyuzin |b M. V. |g Mikhail | |
| 701 | 1 | |a Timin |b A. S. |c Chemist |c Associate Scientist of Tomsk Polytechnic University |f 1989- |g Aleksandr Sergeevich |3 (RuTPU)RU\TPU\pers\37036 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Исследовательская школа химических и биомедицинских технологий |c (2017- ) |3 (RuTPU)RU\TPU\col\23537 |
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