Modification of PCL Scaffolds by Reactive Magnetron Sputtering: A Possibility for Modulating Macrophage Responses

Modification of PCL Scaffolds by Reactive Magnetron Sputtering: A Possibility for Modulating Macrophage Responses

Bibliografiset tiedot
Parent link:ACS Biomaterials Science & Engineering
Vol. 6, iss. 7.— 2020.— [P. 3967–3974]
Yhteisötekijä: Национальный исследовательский Томский политехнический университет Инженерная школа ядерных технологий Научно-образовательный центр Б. П. Вейнберга
Muut tekijät: Stankevich K. S. Ksenia Sergeevna, Kudryavtseva V. L. Valeriya Lvovna, Bolbasov E. N. Evgeny Nikolaevich, Shesterikov E. V. Evgeny Viktorovich, Larionova I. V. Irina, Shapovalova E. Elena, Domracheva L. V. Liubov Vladimirovna, Volokhova A. A. Apollinariya Aleksandrovna, Kurzina I. A. Irina Aleksandrovna, Zhukov Yu. M. Yuriy Mikhaylovich, Malashicheva A. B. Anna Borisovna, Kzhyshkovska Yu. G. Yuliya Georgievna, Tverdokhlebov S. I. Sergei Ivanovich
Yhteenveto:Title screen
Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ε-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited coating, and their interaction with immune cells remain unknown. Herein, we demonstrated that the DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogen-containing moieties and the titanium dioxide coating on the scaffold surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of the titanium target could be an effective tool to control macrophage functional responses toward PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity.
Режим доступа: по договору с организацией-держателем ресурса
Julkaistu: 2020
Aiheet:
электронный ресурс
труды учёных ТПУ
immunology
scaffolds
plasma
titanium
polymer scaffolds
иммунология
строительные леса
плазма
титан
полимерные каркасы
Linkit:https://doi.org/10.1021/acsbiomaterials.0c00440
Aineistotyyppi: Elektroninen Kirjan osa
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=663444
Kuvaus
Yhteenveto:Title screen
Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ε-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited coating, and their interaction with immune cells remain unknown. Herein, we demonstrated that the DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogen-containing moieties and the titanium dioxide coating on the scaffold surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of the titanium target could be an effective tool to control macrophage functional responses toward PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity.
Режим доступа: по договору с организацией-держателем ресурса
DOI:10.1021/acsbiomaterials.0c00440

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