Cardioprotective Properties of Opioid Receptor Agonists in Rats WithStress-Induced Cardiac Injury; Physiological Research; Vol. 68, iss. 3

Cardioprotective Properties of Opioid Receptor Agonists in Rats WithStress-Induced Cardiac Injury; Physiological Research; Vol. 68, iss. 3

Bibliographic Details
Parent link:Physiological Research
Vol. 68, iss. 3.— 2019.— [P. 375-384]
Corporate Author: Национальный исследовательский Томский политехнический университет Физико-технический институт Лаборатория № 31 ядерного реактора
Other Authors: Prokudina E. S. Ekaterina Sergeevna, Maslov L. N. Leonid Nikolaevich, Naryzhnaya N. V. Nataliya Vladimirovna, Tsybulnikov S. Yu. Sergey Yurjevich, Lishmanov Yu. B. Yury Borisovich, Madias J. E. John, Oeltgen P. R. Peter
Summary:Title screen
The objectives of this study were to investigate the role of endogenous opioids in the mediation of stress-induced cardiomyopathy (SIC), and to evaluate which opioid receptors regulate heart resistance to immobilization stress. Wistar rats were subjected to 24 h immobilization stress. Stress-induced heart injury was assessed by 99mTc-pyrophosphate accumulation in the heart. The opioid receptor (OR) antagonists (naltrexone, NxMB - naltrexone methyl bromide, MR 2266, ICI 174.864) and agonists (DALDA, DAMGO, DSLET, U-50,488) were administered intraperitoneally prior to immobilization and 12 h after the start of stress. In addition, the selective µ OR agonists PL017 and DAMGO were administered intracerebroventricularly prior to stress. Finally pretreatment with guanethidine was used. Naltrexone did not alter the cardiac 99mTc-PP accumulation in stressed rats. NxMB aggravated stress-induced cardiomyopathy (P=0.005) (SIC). The selective µ OR agonist DALDA, which does not cross the blood-brain barrier, completely prevented (P=0.006) SIC. The µ OR agonist DAMGO exhibited weaker effect than DALDA. The selective δ ligand (DSLET) and κ OR ligand (U-50,488) did not alter stress-induced 99mTc-pyrophosphate accumulation in the heart. Intracerebroventricular administration of the µ OR agonists aggravated SIC. Pretreatment with guanethidine abolished this effect (P=0.01). Guanethidine alone exhibited cardioprotective properties. A stimulation of central µ OR promotes an appearance of SIC. In contrast, stimulation of peripheral µ OR contributes to an increase in cardiac tolerance to stress.
Language:English
Published: 2019
Subjects:
электронный ресурс
труды учёных ТПУ
99mTc-pyrophosphate
opioid receptors
tako-tsubo syndrome
stress
cardiomyopathy
опиоиды
стресс
Online Access:https://doi.org/10.33549/physiolres.933946
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=663259

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