Cellular and Molecular Basis of Osteoblastic and Vascular Niches in the Processes of Hematopoiesis and Bone Remodeling (A Short Review of Modern Views); Current Pharmaceutical Design; Vol. 25, iss. 6

Cellular and Molecular Basis of Osteoblastic and Vascular Niches in the Processes of Hematopoiesis and Bone Remodeling (A Short Review of Modern Views); Current Pharmaceutical Design; Vol. 25, iss. 6

Bibliographic Details
Parent link:Current Pharmaceutical Design
Vol. 25, iss. 6.— 2019.— [P. 663-669]
Corporate Author: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий (ИШХБМТ)
Other Authors: Yurova K. A., Khaziakhmatova O. G., Melashchenko E. S., Melashchenko V. V., Shunkin E. O. Egor, Shupletsova V. V. Valeria, Ivanov P. A. Pavel, Khlusov I. A. Igor Albertovich, Litvinova L. S.
Summary:Title screen
In evolutionary processes, human bone marrow has formed as an organ depot of various types of cells that arise from hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Vital HSC activity is controlled through molecular interactions with the niche microenvironment. The review describes current views on the formation of key molecular and cellular components of the HSC niche, which ensure maintenance of home ostasis in stem cell niches, obtained from studies of their role in regulating the proliferation and differentiation of HSCs, including the physiological, reparative and pathological remodeling of bone tissue. Due to rapid developments in biotechnology, tissue bioengineering, and regenerative medicine, information can be useful for developing biomimetic and bioinspired materials and implants that provide an effective bone/bone marrow recovery process after injuries and, to a greater extent, diseases of various etiologies.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2019
Subjects:
электронный ресурс
труды учёных ТПУ
стволовые клетки
биоматериалы
кости
внеклеточный матрикс
кроветворно-лимфатическая система
биоинженерия
extracellular matrix
biomaterials
bone
tissue remodeling.
Online Access:https://doi.org/10.2174/1381612825666190329153626
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=663002

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