Immunostimulating Activity of Gold-modified Nanodiamond Particles; Anti-Infective Agents; Vol. 18, iss. 1
| Parent link: | Anti-Infective Agents Vol. 18, iss. 1.— 2020.— [P. 54-58] |
|---|---|
| Kurumsal yazarlar: | , |
| Diğer Yazarlar: | , , , |
| Özet: | Title screen Background: The fight against infectious diseases includes two main components – immediate direct anti-infective action and stimulation of one's own immunity. Objective: In this study, we investigated the properties of diamond nanoparticles modified with gold. The use of such gold nanoparticles as indirect anti-infectious agents and immunostimulators has certain prospects. Materials and Methods: Gold hydrosols were synthesized by the reduction in an aqueous solution of gold (III) with sodium citrate (Na3Cit) under heating. Modification procedure of nanodiamond by gold requires incubation, a small sample of nanodiamond in a defined volume of a gold sol for about 24 hours in a dark place. We use human blood cells as test objects. The reaction of blastic transformation of lymphocytes was applied here as a test of biological actions of modified nanodiamond. Results: Modified nanodiamond do not have a toxic influence on blood cells. Modified nanodiamond possesses stimulation effects on spontaneous proliferation of lymphocytes and does not significantly affect phytohemagglutinin-induced proliferation. Nanodiamond slightly increases phagocytosis parameters of neutrophil leucocytes. Conclusion: Thus, results showed that the nanodiamond modified by gold possesses immunostimulating activity, increases the phagocytic activity of neutrophilic leukocytes and stimulates lymphocytes in the spontaneous proliferation test. Gold-modified nanodiamond could be considered as a non-direct anti-infective agent through immune stimulation. [References: 19 tit.] Режим доступа: по договору с организацией-держателем ресурса |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
2020
|
| Konular: | |
| Online Erişim: | https://doi.org/10.2174/2211352517666190328122008 |
| Materyal Türü: | Elektronik Kitap Bölümü |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662980 |
MARC
| LEADER | 00000naa0a2200000 4500 | ||
|---|---|---|---|
| 001 | 662980 | ||
| 005 | 20250421125010.0 | ||
| 035 | |a (RuTPU)RU\TPU\network\34148 | ||
| 035 | |a RU\TPU\network\27979 | ||
| 090 | |a 662980 | ||
| 100 | |a 20210118d2020 k||y0rusy50 ba | ||
| 101 | 0 | |a eng | |
| 135 | |a drcn ---uucaa | ||
| 181 | 0 | |a i | |
| 182 | 0 | |a b | |
| 200 | 1 | |a Immunostimulating Activity of Gold-modified Nanodiamond Particles |f E. V. Plotnikov, N. A. Skorik, D. S. Saveljev, V. M. Plotnikov | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 330 | |a Background: The fight against infectious diseases includes two main components – immediate direct anti-infective action and stimulation of one's own immunity. Objective: In this study, we investigated the properties of diamond nanoparticles modified with gold. The use of such gold nanoparticles as indirect anti-infectious agents and immunostimulators has certain prospects. Materials and Methods: Gold hydrosols were synthesized by the reduction in an aqueous solution of gold (III) with sodium citrate (Na3Cit) under heating. Modification procedure of nanodiamond by gold requires incubation, a small sample of nanodiamond in a defined volume of a gold sol for about 24 hours in a dark place. We use human blood cells as test objects. The reaction of blastic transformation of lymphocytes was applied here as a test of biological actions of modified nanodiamond. Results: Modified nanodiamond do not have a toxic influence on blood cells. Modified nanodiamond possesses stimulation effects on spontaneous proliferation of lymphocytes and does not significantly affect phytohemagglutinin-induced proliferation. Nanodiamond slightly increases phagocytosis parameters of neutrophil leucocytes. Conclusion: Thus, results showed that the nanodiamond modified by gold possesses immunostimulating activity, increases the phagocytic activity of neutrophilic leukocytes and stimulates lymphocytes in the spontaneous proliferation test. Gold-modified nanodiamond could be considered as a non-direct anti-infective agent through immune stimulation. | ||
| 330 | |a [References: 19 tit.] | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Anti-Infective Agents | ||
| 463 | |t Vol. 18, iss. 1 |v [P. 54-58] |d 2020 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a nanodiamond | |
| 610 | 1 | |a gold nanoparticle | |
| 610 | 1 | |a lymphocytes | |
| 610 | 1 | |a phagocytosis | |
| 610 | 1 | |a immunostimulation | |
| 610 | 1 | |a neutrophilic leukocytes | |
| 610 | 1 | |a наноалмазы | |
| 610 | 1 | |a наночастицы | |
| 610 | 1 | |a лимфоциты | |
| 610 | 1 | |a фагоцитоз | |
| 701 | 1 | |a Plotnikov |b E. V. |c chemist |c Associate Professor of Tomsk Polytechnic University, Candidate of Chemical Sciences |f 1983- |g Evgeny Vladimirovich |3 (RuTPU)RU\TPU\pers\32469 |9 16417 | |
| 701 | 1 | |a Skorik |b N. A. | |
| 701 | 1 | |a Saveljev |b D. S. | |
| 701 | 1 | |a Plotnikov |b V. M. |g Vladimir Mikhaylovich | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Инженерная школа природных ресурсов |b Отделение химической инженерии |3 (RuTPU)RU\TPU\col\23513 |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Исследовательская школа химических и биомедицинских технологий |c (2017- ) |3 (RuTPU)RU\TPU\col\23537 |
| 801 | 2 | |a RU |b 63413507 |c 20210118 |g RCR | |
| 850 | |a 63413507 | ||
| 856 | 4 | |u https://doi.org/10.2174/2211352517666190328122008 | |
| 942 | |c CF | ||