Continuous Normobaric Hypoxia Improved Cardiac Bioenergetics after Ischemia/Reperfusion: Role of Opioid Receptors

Continuous Normobaric Hypoxia Improved Cardiac Bioenergetics after Ischemia/Reperfusion: Role of Opioid Receptors

Dettagli Bibliografici
Parent link:	Bulletin of Experimental Biology and Medicine Vol. 169, iss. 1.— 2020.— [P. 13-17]
Ente Autore:	Национальный исследовательский Томский политехнический университет Физико-технический институт Лаборатория радиационного контроля № 31
Altri autori:	Prokudina E. S. Ekaterina Sergeevna, Naryzhnaya N. V. Nataliya Vladimirovna, Nesterov E. A. Evgeny Alexandrovich, Tsybulnikov S. Yu. Sergey Yurjevich, Maslov L. N. Leonid Nikolaevich
Riassunto:	Title screen We analyzed the role of opioid receptors in the conditioning effect of continuous normobaric hypoxia on bioenergetics of the heart subjected to ischemia/reperfusion injury. Male Wistar rats were adapted to a 21-day continuous normobaric hypoxia (12% pO2). Then, the hearts were isolated and subjected to 45-min total ischemia followed by 30-min reperfusion. Damage to the myocardium was assessed by activity of creatine phosphokinase in the perfusate. Experiments on isolated mitochondria showed that ischemia/reperfusion injury decreased the respiration rate in state 3 (V3), the ratio of added ADP and oxygen consumption in respiration state 3 (ADP/O ratio), the mitochondrial potential across the inner membrane (Δψ), and Ca2+ binding capacity of mitochondria. In addition, ischemia/reperfusion injury decreased myocardial ATP. Preventive continuous normobaric hypoxia pronouncedly moderated these adverse effects of reperfusion. It was found that its protective effects were related to activation of cardiac μ- and δ2-opioid receptors. Режим доступа: по договору с организацией-держателем ресурса
Lingua:	inglese
Pubblicazione:	2020
Soggetti:	электронный ресурс труды учёных ТПУ heart mitochondria adaptation hypoxia opioid receptors сердце митохондрии приспособление гипоксия опиоиды
Accesso online:	https://doi.org/10.1007/s10517-020-04814-9
Natura:	Elettronico Capitolo di libro
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662951

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