Continuous Normobaric Hypoxia Improved Cardiac Bioenergetics after Ischemia/Reperfusion: Role of Opioid Receptors; Bulletin of Experimental Biology and Medicine; Vol. 169, iss. 1
| Parent link: | Bulletin of Experimental Biology and Medicine Vol. 169, iss. 1.— 2020.— [P. 13-17] |
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| Співавтор: | |
| Інші автори: | , , , , |
| Резюме: | Title screen We analyzed the role of opioid receptors in the conditioning effect of continuous normobaric hypoxia on bioenergetics of the heart subjected to ischemia/reperfusion injury. Male Wistar rats were adapted to a 21-day continuous normobaric hypoxia (12% pO2). Then, the hearts were isolated and subjected to 45-min total ischemia followed by 30-min reperfusion. Damage to the myocardium was assessed by activity of creatine phosphokinase in the perfusate. Experiments on isolated mitochondria showed that ischemia/reperfusion injury decreased the respiration rate in state 3 (V3), the ratio of added ADP and oxygen consumption in respiration state 3 (ADP/O ratio), the mitochondrial potential across the inner membrane (Δψ), and Ca2+ binding capacity of mitochondria. In addition, ischemia/reperfusion injury decreased myocardial ATP. Preventive continuous normobaric hypoxia pronouncedly moderated these adverse effects of reperfusion. It was found that its protective effects were related to activation of cardiac μ- and δ2-opioid receptors. Режим доступа: по договору с организацией-держателем ресурса |
| Мова: | Англійська |
| Опубліковано: |
2020
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| Предмети: | |
| Онлайн доступ: | https://doi.org/10.1007/s10517-020-04814-9 |
| Формат: | Електронний ресурс Частина з книги |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662951 |
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| 200 | 1 | |a Continuous Normobaric Hypoxia Improved Cardiac Bioenergetics after Ischemia/Reperfusion: Role of Opioid Receptors |f E. S. Prokudina, N. V. Naryzhnaya, E. A. Nesterov [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 15 tit.] | ||
| 330 | |a We analyzed the role of opioid receptors in the conditioning effect of continuous normobaric hypoxia on bioenergetics of the heart subjected to ischemia/reperfusion injury. Male Wistar rats were adapted to a 21-day continuous normobaric hypoxia (12% pO2). Then, the hearts were isolated and subjected to 45-min total ischemia followed by 30-min reperfusion. Damage to the myocardium was assessed by activity of creatine phosphokinase in the perfusate. Experiments on isolated mitochondria showed that ischemia/reperfusion injury decreased the respiration rate in state 3 (V3), the ratio of added ADP and oxygen consumption in respiration state 3 (ADP/O ratio), the mitochondrial potential across the inner membrane (Δψ), and Ca2+ binding capacity of mitochondria. In addition, ischemia/reperfusion injury decreased myocardial ATP. Preventive continuous normobaric hypoxia pronouncedly moderated these adverse effects of reperfusion. It was found that its protective effects were related to activation of cardiac μ- and δ2-opioid receptors. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Bulletin of Experimental Biology and Medicine | ||
| 463 | |t Vol. 169, iss. 1 |v [P. 13-17] |d 2020 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a heart | |
| 610 | 1 | |a mitochondria | |
| 610 | 1 | |a adaptation | |
| 610 | 1 | |a hypoxia | |
| 610 | 1 | |a opioid receptors | |
| 610 | 1 | |a сердце | |
| 610 | 1 | |a митохондрии | |
| 610 | 1 | |a приспособление | |
| 610 | 1 | |a гипоксия | |
| 610 | 1 | |a опиоиды | |
| 701 | 1 | |a Prokudina |b E. S. |g Ekaterina Sergeevna | |
| 701 | 1 | |a Naryzhnaya |b N. V. |g Nataliya Vladimirovna | |
| 701 | 1 | |a Nesterov |b E. A. |c Physicist, Specialist in the field of nuclear power engineering |c Researcher of Tomsk Polytechnic University |f 1976- |g Evgeny Alexandrovich |3 (RuTPU)RU\TPU\pers\32657 |9 16556 | |
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| 701 | 1 | |a Maslov |b L. N. |g Leonid Nikolaevich | |
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