Multiresponsive Hybrid Microparticles for Stimuli-Responsive Delivery of Bioactive Compounds
| Parent link: | Applied Sciences Vol. 10, iss. 12.— 2020.— [4324, 14 p.] |
|---|---|
| Corporate Author: | |
| Other Authors: | , , , , , , |
| Summary: | Title screen Hybrid microparticles based on an iron core and an amphiphilic polymeric shell have been prepared to respond simultaneously to magnetic and ultrasonic fields and variation in the surrounding pH to trigger and modulate the delivery of doxorubicin. The microparticles have been developed in four steps: (i) synthesis of the iron core; (ii) surface modification of the core; (iii) conjugation with the amphiphilic poly(lactic acid)-grafted chitosan; and (iv) doxorubicin loading. The particles demonstrate spherical shape, a size in the range of 1–3 µm and surface charge that is tuneable by changing the pH of the environment. The microparticles demonstrate good stability in simulated physiological solutions and are able to hold up to 400 µg of doxorubicin per mg of dried particles. The response to ultrasound and the changes in the shell structure during exposure to different pH levels allows the control of the burst intensity and release rate of the payload. Additionally, the magnetic response of the iron core is preserved despite the polymer coat. In vitro cytotoxicity tests performed on fibroblast NIH/3T3 demonstrate a reduction in the cell viability after administration of doxorubicin-loaded microparticles compared to the administration of free doxorubicin. The application of ultrasound causes a burst in the release of the doxorubicin from the carrier, causing a decrease in cell viability. The microparticles demonstrate in vitro cytocompatibility and hemocompatibility at concentrations of up to 50 and 60 µg/mL, respectively. |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://doi.org/10.3390/app10124324 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662913 |
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| 200 | 1 | |a Multiresponsive Hybrid Microparticles for Stimuli-Responsive Delivery of Bioactive Compounds |f S. S. Vlasov, P. S. Postnikov, M. V. Belousov [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 42 tit.] | ||
| 330 | |a Hybrid microparticles based on an iron core and an amphiphilic polymeric shell have been prepared to respond simultaneously to magnetic and ultrasonic fields and variation in the surrounding pH to trigger and modulate the delivery of doxorubicin. The microparticles have been developed in four steps: (i) synthesis of the iron core; (ii) surface modification of the core; (iii) conjugation with the amphiphilic poly(lactic acid)-grafted chitosan; and (iv) doxorubicin loading. The particles demonstrate spherical shape, a size in the range of 1–3 µm and surface charge that is tuneable by changing the pH of the environment. The microparticles demonstrate good stability in simulated physiological solutions and are able to hold up to 400 µg of doxorubicin per mg of dried particles. The response to ultrasound and the changes in the shell structure during exposure to different pH levels allows the control of the burst intensity and release rate of the payload. Additionally, the magnetic response of the iron core is preserved despite the polymer coat. In vitro cytotoxicity tests performed on fibroblast NIH/3T3 demonstrate a reduction in the cell viability after administration of doxorubicin-loaded microparticles compared to the administration of free doxorubicin. The application of ultrasound causes a burst in the release of the doxorubicin from the carrier, causing a decrease in cell viability. The microparticles demonstrate in vitro cytocompatibility and hemocompatibility at concentrations of up to 50 and 60 µg/mL, respectively. | ||
| 461 | |t Applied Sciences | ||
| 463 | |t Vol. 10, iss. 12 |v [4324, 14 p.] |d 2020 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a core–shell microparticles | |
| 610 | 1 | |a ultrasound | |
| 610 | 1 | |a amphiphilic polymers | |
| 610 | 1 | |a magnetic microparticles | |
| 610 | 1 | |a doxorubicin | |
| 610 | 1 | |a микрочастицы | |
| 610 | 1 | |a ультразвук | |
| 610 | 1 | |a амфифильные структуры | |
| 610 | 1 | |a доксорубицин | |
| 701 | 1 | |a Vlasov |b S. S. |g Sergey Sergeevich | |
| 701 | 1 | |a Postnikov |b P. S. |c organic chemist |c Associate Professor of Tomsk Polytechnic University, Candidate of chemical sciences |f 1984- |g Pavel Sergeevich |3 (RuTPU)RU\TPU\pers\31287 |9 15465 | |
| 701 | 1 | |a Belousov |b M. V. |c chemist |c Professor of Tomsk Polytechnic University, Doctor of Pharmaceutical Sciences |f 1963- |g Mikhail Valerievich |3 (RuTPU)RU\TPU\pers\45418 |9 21924 | |
| 701 | 1 | |a Krivoshchekov |b S. V. |c chemist |c engineer of Tomsk Polytechnic University |f 1987- |g Sergey Vladimirovich |3 (RuTPU)RU\TPU\pers\34574 |9 17936 | |
| 701 | 1 | |a Yusubov |b M. S. |c chemist |c Professor of Tomsk Polytechnic University, Doctor of chemical sciences |f 1961- |g Mekhman Suleiman-Ogly (Suleimanovich) |3 (RuTPU)RU\TPU\pers\31833 |9 15928 | |
| 701 | 1 | |a Gurjev |b A. M. |g Artem Mikhaylovich | |
| 701 | 1 | |a Di Martino |b A. |c organic chemist |c research of Tomsk Polytechnic University |f 1984- |g Antonio |3 (RuTPU)RU\TPU\pers\39440 |9 20983 | |
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