Magnetron plasma mediated immobilization of hyaluronic acid for the development of functional double-sided biodegradable vascular graft; Applied Surface Science; Vol. 529
| Parent link: | Applied Surface Science Vol. 529.— 2020.— [147196, 9 p.] |
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| Coauteur: | |
| Andere auteurs: | , , , , , , , , , , |
| Samenvatting: | Title screen The clinical need for vascular grafts is associated with cardiovascular diseases frequently leading to fatal outcomes. Artificial vessels based on bioresorbable polymers can replace the damaged vascular tissue or create a bypass path for blood flow while stimulating regeneration of a blood vessel in situ. However, the problem of proper conditions for the cells to grow on the vascular graft from the adventitia while maintaining its mechanical integrity of the luminal surface remains a challenge. In this work, we propose a two-stage technology for processing electrospun vascular graft from polycaprolactone, which consists of plasma treatment and subsequent immobilization of hyaluronic acid on its surface producing thin double-sided graft with one hydrophilic and one hydrophobic side. Plasma modification activates the polymer surfaces and produces a thin layer for linker-free immobilisation of bioactive molecules, thereby producing materials with unique properties. Proposed modification does not affect the morphology or mechanical properties of the graft and improves cell adhesion. The proposed approach can potentially be used for various biodegradable polymers such as polylactic acid, polyglycolide and their copolymers and blends, with a hydrophilic inner surface and a hydrophobic outer surface. Режим доступа: по договору с организацией-держателем ресурса |
| Taal: | Engels |
| Gepubliceerd in: |
2020
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| Onderwerpen: | |
| Online toegang: | https://doi.org/10.1016/j.apsusc.2020.147196 |
| Formaat: | Elektronisch Hoofdstuk |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662872 |
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| 200 | 1 | |a Magnetron plasma mediated immobilization of hyaluronic acid for the development of functional double-sided biodegradable vascular graft |f V. L. Kudryavtseva, K. S. Stankevich, A. I. Kozelskaya [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 48 tit.] | ||
| 330 | |a The clinical need for vascular grafts is associated with cardiovascular diseases frequently leading to fatal outcomes. Artificial vessels based on bioresorbable polymers can replace the damaged vascular tissue or create a bypass path for blood flow while stimulating regeneration of a blood vessel in situ. However, the problem of proper conditions for the cells to grow on the vascular graft from the adventitia while maintaining its mechanical integrity of the luminal surface remains a challenge. In this work, we propose a two-stage technology for processing electrospun vascular graft from polycaprolactone, which consists of plasma treatment and subsequent immobilization of hyaluronic acid on its surface producing thin double-sided graft with one hydrophilic and one hydrophobic side. Plasma modification activates the polymer surfaces and produces a thin layer for linker-free immobilisation of bioactive molecules, thereby producing materials with unique properties. Proposed modification does not affect the morphology or mechanical properties of the graft and improves cell adhesion. The proposed approach can potentially be used for various biodegradable polymers such as polylactic acid, polyglycolide and their copolymers and blends, with a hydrophilic inner surface and a hydrophobic outer surface. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Applied Surface Science | ||
| 463 | |t Vol. 529 |v [147196, 9 p.] |d 2020 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a polycaprolactone | |
| 610 | 1 | |a hyaluronic acid | |
| 610 | 1 | |a plasma | |
| 610 | 1 | |a electrospinning | |
| 610 | 1 | |a vascular graft | |
| 610 | 1 | |a superhydrophilicity | |
| 610 | 1 | |a поликапролактон | |
| 610 | 1 | |a гиалуроновая кислота | |
| 610 | 1 | |a плазма | |
| 610 | 1 | |a электроспиннинг | |
| 610 | 1 | |a трансплантаты | |
| 701 | 1 | |a Kudryavtseva |b V. L. |c physicist |c Engineer of Tomsk Polytechnic University |f 1993- |g Valeriya Lvovna |3 (RuTPU)RU\TPU\pers\38564 |9 20822 | |
| 701 | 1 | |a Stankevich |b K. S. |c Physicist |c Engineer Tomsk Polytechnic University |f 1992- |g Ksenia Sergeevna |3 (RuTPU)RU\TPU\pers\37546 |9 20415 | |
| 701 | 1 | |a Kozelskaya |b A. I. |c physicist |c Researcher at Tomsk Polytechnic University, Candidate of Physical and Mathematical Sciences |f 1985- |g Anna Ivanovna |3 (RuTPU)RU\TPU\pers\39663 |9 21044 | |
| 701 | 1 | |a Kibler |b E. V. |c specialist in the field of nuclear technologies |c Engineer of Tomsk Polytechnic University |f 1995- |g Elina Vitaljevna |3 (RuTPU)RU\TPU\pers\46672 |9 22328 | |
| 701 | 1 | |a Zhukov |b Yu. M. |g Yuriy Mikhaylovich | |
| 701 | 1 | |a Malashicheva |b A. B. |g Anna Borisovna | |
| 701 | 1 | |a Golovkin |b A. S. |g Aleksey Sergeevich | |
| 701 | 1 | |a Mishanin |b A. I. |g Aleksandr Igorevich | |
| 701 | 1 | |a Filimonov |b V. D. |c Russian chemist |c Professor of the TPU |f 1945- |g Viktor Dmitrievich |3 (RuTPU)RU\TPU\pers\26423 |9 12127 | |
| 701 | 1 | |a Bolbasov |b E. N. |c physicist |c Senior Researcher at Tomsk Polytechnic University, Candidate of Technical Sciences |f 1981- |g Evgeny Nikolaevich |3 (RuTPU)RU\TPU\pers\30857 |9 15103 | |
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