Association of ANKK1 polymorphism with antipsychotic‐induced hyperprolactinemia; Human Psychopharmacology: Clinical and Experimental; Vol. 35, iss. 4

Association of ANKK1 polymorphism with antipsychotic‐induced hyperprolactinemia; Human Psychopharmacology: Clinical and Experimental; Vol. 35, iss. 4

書誌詳細
Parent link:	Human Psychopharmacology: Clinical and Experimental Vol. 35, iss. 4.— 2020.— [e2737, 8 p.]
団体著者:	Национальный исследовательский Томский политехнический университет Инженерная школа неразрушающего контроля и безопасности Отделение контроля и диагностики
その他の著者:	Fedorenko O. Yu. Olga Yurievna, Paderina D. Z. Diana, Loonen A. J. M. Anton, Pozhidaev I. V. Ivan, Boyko A. S., Kornetova E. G. Elena Georgievna, Bokhan N. A. Nikolay Aleksandrovich, Wilffert B. Bob, Ivanova S. A. Svetlana Aleksandrovna
要約:	Title screen Objective: Schizophrenia is a severe highly heritable mental disorder. Genetic polymorphisms of dopaminergic pathways are related to pathogenesis of drug response. Hyperprolactinemia (HPRL), a common adverse effect of antipsychotics, is attributed to blockade of dopamine D2 receptors. Ankyrin Repeat and Kinase Domain containing 1 (ANKK1) gene is closely related to Dopamine Receptor D2 type (DRD2) gene functioning. We examined whether the functional polymorphism rs2734849 in the ANKK1 gene is associated with antipsychotic?induced HPRL. Methods: We recruited 446 patients with schizophrenia from among the Russian population of the Siberian region. The polymorphism rs2734849 in the ANKK1 gene was genotyped with The MassARRAY® Analyzer 4 by Agena Bioscience™, using the kit SEQUENOM Consumables iPLEXGold 384. Genotype and allele frequencies were compared between groups of schizophrenia patients with and without HPRL using the ?2 test. Results: A comparison between schizophrenia patients with and without HPRL revealed significantly higher frequency of the C allele of the polymorphic variant rs2734849 in the ANKK1 gene in patients with HPRL as compared to the patients without it (?2 = 3.70; p = .05; odds ratio [OR] = 1.30 [0.99–1.69]).
言語:	英語
出版事項:	2020
主題:	электронный ресурс труды учёных ТПУ ANKK1 hyperprolactinemia polymorphism schizophrenia полиморфизм шизофрения
オンライン･アクセス:	https://doi.org/10.1002/hup.2737
フォーマット:	電子媒体図書の章
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662600

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