Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer; EJNMMI Research; Vol. 10, iss. 1

Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer; EJNMMI Research; Vol. 10, iss. 1

Bibliographic Details
Parent link:EJNMMI Research
Vol. 10, iss. 1.— 2020.— [21, 10 p.]
Corporate Author: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Other Authors: Alhuseinalkhudhur A. Ali, Lubberink M. Mark, Lindman H. Henrik, Tolmachev V. M. Vladimir Maksimilianovich, Frejd F. Y. Fredrik, Feldwisch J. Joachim, Velikyan I. Irina, Sorensen J. Jens
Summary:Title screen
High expression of human epidermal growth factor receptor type 2 (HER2) represents an aggressive subtype of breast cancer. Anti-HER2 treatment requires a theragnostic approach wherein sufficiently high receptor expression in biopsy material is mandatory. Heterogeneity and discordance of HER2 expression between primary tumour and metastases, as well as within a lesion, present a complication for the treatment and require multiple biopsies. Molecular imaging using the HER2-targeting Affibody peptide ABY-025 radiolabelled with 68Ga-gallium for PET/CT is currently under investigation as a non-invasive tool for whole-body evaluation of metastatic HER2 expression. Initial studies demonstrated a high correlation between 68Ga-ABY-025 standardized uptake values (SUVs) and histopathology. However, detecting small liver lesions might be compromised by high background uptake. This study aimed to explore the applicability of kinetic modelling and parametric image analysis for absolute quantification of 68Ga-ABY-025 uptake and HER2-receptor expression and how that relates to static SUVs.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2020
Subjects:
электронный ресурс
труды учёных ТПУ
HER2 receptor
metastatic breast cancer
affibody
dynamic PET
kinetic modelling
рецепторы
метаструктуры
рак
кинетическое моделирование
Online Access:https://doi.org/10.1186/s13550-020-0603-9
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662556

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