Novel multicomponent organic–inorganic WPI/gelatin/CaP hydrogel composites for bone tissue engineering; Journal of Biomedical Materials Research - Part A; Vol. 107, iss. 11

Библиографические подробности
Источник:	Journal of Biomedical Materials Research - Part A Vol. 107, iss. 11.— 2019.— [P. 2479-2491]
Автор-организация:	Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий Научно-исследовательский центр "Физическое материаловедение и композитные материалы"
Другие авторы:	Dziadek M. Michal, Kudlackova R. Radmila, Zima A. Aneta, Slosarczyk A. Anna, Ziabka M. Magdalena, Jelen P. Piotr, Shkarina S. Svetlana, Cecilia A. Angelica, Zuber M. Marcus, Baumbach T. Tilo, Surmeneva M. A. Maria Alexandrovna, Surmenev R. A. Roman Anatolievich
Примечания:	Title screen The present work focuses on the development of novel multicomponent organic–inorganic hydrogel composites for bone tissue engineering. For the first time, combination of the organic components commonly used in food industry, namely whey protein isolate (WPI) and gelatin from bovine skin, as well as inorganic material commonly used as a major component of hydraulic bone cements, namely ??TCP in various concentrations (0–70?wt%) was proposed. The results showed that ??TCP underwent incomplete transformation to calcium?deficient hydroxyapatite (CDHA) during preparation process of the hydrogels. Microcomputer tomography showed inhomogeneous distribution of the calcium phosphate (CaP) phase in the resulting composites. Nevertheless, hydrogels containing 30–70?wt% ??TCP showed significantly improved mechanical properties. The values of Young's modulus and the stresses corresponding to compression of a sample by 50% increased almost linearly with increasing concentration of ceramic phase. Incomplete transformation of ??TCP to CDHA during preparation process of composites provides them high reactivity in simulated body fluid during 14?day incubation. Preliminary in vitro studies revealed that the WPI/gelatin/CaP composite hydrogels support the adhesion, spreading, and proliferation of human osteoblast?like MG?63 cells. The WPI/gelatin/CaP composite hydrogels obtained in this work showed great potential for the use in bone tissue engineering and regenerative medicine applications. Режим доступа: по договору с организацией-держателем ресурса
Язык:	английский
Опубликовано:	2019
Предметы:	электронный ресурс труды учёных ТПУ calcium phosphate gelatin hydrogel composites whey protein isolate фосфат кальция желатин гидрогели
Online-ссылка:	https://doi.org/10.1002/jbm.a.36754
Формат:	Электронный ресурс Статья
Запись в KOHA:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662530