The Role of Cardiac Opioid Receptors in the Cardioprotective Effect of Continuous Normobaric Hypoxia; Bulletin of Experimental Biology and Medicine; Vol. 168, iss. 6
| Parent link: | Bulletin of Experimental Biology and Medicine Vol. 168, iss. 6.— 2020.— [P. 727-729] |
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| מחבר תאגידי: | |
| מחברים אחרים: | , , , , |
| סיכום: | Title screen We studied the role of opioid receptor subtypes in improvement of the functional state ofthe heart during reperfusion after adaptation to continuous normobaric hypoxia. To this end,male Wistar rats were subjected to continuous normobaric hypoxia (12% O2). Then, the heartswere isolated and exposed to total 45-min ischemia followed by 30-min reperfusion. Opioidreceptor antagonists were added to the perfusion solution prior to ischemia. It was foundthat continuous normobaric hypoxia reduced the release of creatine phosphokinase into theeffluent, increased myocardial contractile force, and decreased the end-diastolic pressure during reperfusion; these positive effects were related to activation of cardiac ?2- and µ-opioidreceptors. Режим доступа: по договору с организацией-держателем ресурса |
| שפה: | אנגלית |
| יצא לאור: |
2020
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| נושאים: | |
| גישה מקוונת: | https://doi.org/10.1007/s10517-020-04789-7 |
| פורמט: | אלקטרוני Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662351 |
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| 200 | 1 | |a The Role of Cardiac Opioid Receptors in the Cardioprotective Effect of Continuous Normobaric Hypoxia |f N. V. Naryzhnaya, E. S. Prokudina, E. A. Nesterov [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: p. 729 (9 tit.)] | ||
| 330 | |a We studied the role of opioid receptor subtypes in improvement of the functional state ofthe heart during reperfusion after adaptation to continuous normobaric hypoxia. To this end,male Wistar rats were subjected to continuous normobaric hypoxia (12% O2). Then, the heartswere isolated and exposed to total 45-min ischemia followed by 30-min reperfusion. Opioidreceptor antagonists were added to the perfusion solution prior to ischemia. It was foundthat continuous normobaric hypoxia reduced the release of creatine phosphokinase into theeffluent, increased myocardial contractile force, and decreased the end-diastolic pressure during reperfusion; these positive effects were related to activation of cardiac ?2- and µ-opioidreceptors. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Bulletin of Experimental Biology and Medicine | ||
| 463 | |t Vol. 168, iss. 6 |v [P. 727-729] |d 2020 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a heart | |
| 610 | 1 | |a adaptation | |
| 610 | 1 | |a hypoxia | |
| 610 | 1 | |a opioid receptors | |
| 610 | 1 | |a сердце | |
| 610 | 1 | |a приспособление | |
| 610 | 1 | |a гипоксия | |
| 701 | 1 | |a Naryzhnaya |b N. V. |g Nataliya Vladimirovna | |
| 701 | 1 | |a Prokudina |b E. S. |g Ekaterina Sergeevna | |
| 701 | 1 | |a Nesterov |b E. A. |c Physicist, Specialist in the field of nuclear power engineering |c Researcher of Tomsk Polytechnic University |f 1976- |g Evgeny Alexandrovich |3 (RuTPU)RU\TPU\pers\32657 |9 16556 | |
| 701 | 1 | |a Tsibulnikov |b S. Yu. |c specialist in the field of medical technology |c Senior Lecturer of Tomsk Polytechnic University, Candidate of medical Sciences |f 1986- |g Sergey Yurjevich |3 (RuTPU)RU\TPU\pers\36547 |9 19595 | |
| 701 | 1 | |a Maslov |b L. N. |g Leonid Nikolaevich | |
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