The Role of Cardiac Opioid Receptors in the Cardioprotective Effect of Continuous Normobaric Hypoxia; Bulletin of Experimental Biology and Medicine; Vol. 168, iss. 6
| Parent link: | Bulletin of Experimental Biology and Medicine Vol. 168, iss. 6.— 2020.— [P. 727-729] |
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| Autor kompanije: | |
| Daljnji autori: | , , , , |
| Sažetak: | Title screen We studied the role of opioid receptor subtypes in improvement of the functional state ofthe heart during reperfusion after adaptation to continuous normobaric hypoxia. To this end,male Wistar rats were subjected to continuous normobaric hypoxia (12% O2). Then, the heartswere isolated and exposed to total 45-min ischemia followed by 30-min reperfusion. Opioidreceptor antagonists were added to the perfusion solution prior to ischemia. It was foundthat continuous normobaric hypoxia reduced the release of creatine phosphokinase into theeffluent, increased myocardial contractile force, and decreased the end-diastolic pressure during reperfusion; these positive effects were related to activation of cardiac ?2- and µ-opioidreceptors. Режим доступа: по договору с организацией-держателем ресурса |
| Jezik: | engleski |
| Izdano: |
2020
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| Teme: | |
| Online pristup: | https://doi.org/10.1007/s10517-020-04789-7 |
| Format: | Elektronički Poglavlje knjige |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662351 |
| Sažetak: | Title screen We studied the role of opioid receptor subtypes in improvement of the functional state ofthe heart during reperfusion after adaptation to continuous normobaric hypoxia. To this end,male Wistar rats were subjected to continuous normobaric hypoxia (12% O2). Then, the heartswere isolated and exposed to total 45-min ischemia followed by 30-min reperfusion. Opioidreceptor antagonists were added to the perfusion solution prior to ischemia. It was foundthat continuous normobaric hypoxia reduced the release of creatine phosphokinase into theeffluent, increased myocardial contractile force, and decreased the end-diastolic pressure during reperfusion; these positive effects were related to activation of cardiac ?2- and µ-opioidreceptors. Режим доступа: по договору с организацией-держателем ресурса |
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| Digitalni identifikator objekta: | 10.1007/s10517-020-04789-7 |